180847-22-7

Upstream product

• 6457-49-4 4-piperidinemethanol 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 921596-17-0 N-tert-butoxycarbonyl-4-[4-(3,5-dimethyl-4-bromothiophen-2-yl)phenoxymethyl]piperidine 
• 180847-26-1 4-(4-iodophenoxymethyl)piperidine 

Relevant academic research and scientific papers

Synthesis of a selective sigma receptor radioligand for SPECT: [123I]-1-(2-Hydroxyethyl)-4-(4-iodophenoxymethyl)piperidine

[123I]-1-(2-Hydroxyethyl)-4-(4-iodophenoxymethyl)piperidine has been prepared as a novel sigma receptor radioligand for tumour imaging by SPECT. This ligand was found to be selective in vitro for the sigma-1 receptor (Ki = 2.3 nM) when tested in a variety of neuroreceptor binding assays. The lipophilicity of this ligand is appropriate for crossing the blood/brain barrier (log P7.5 = 4.0). Radioiodination was accomplished by no-carrier- added iododestannylation using chloramine-T in acetic acid. The specific activity of the radiotracer >10,000 mCi/μmole. The radiochemical yield was 63-77% EOS and the radiochemical purity was >99%.