Journal of labelled compounds and radiopharmaceuticals p. 595 - 605 (1996)
Update date:2022-09-26
Topics:
Waterhouse, Rikki N.
Collier, T. Lee
O'Brien
[123I]-1-(2-Hydroxyethyl)-4-(4-iodophenoxymethyl)piperidine has been prepared as a novel sigma receptor radioligand for tumour imaging by SPECT. This ligand was found to be selective in vitro for the sigma-1 receptor (Ki = 2.3 nM) when tested in a variety of neuroreceptor binding assays. The lipophilicity of this ligand is appropriate for crossing the blood/brain barrier (log P7.5 = 4.0). Radioiodination was accomplished by no-carrier- added iododestannylation using chloramine-T in acetic acid. The specific activity of the radiotracer >10,000 mCi/μmole. The radiochemical yield was 63-77% EOS and the radiochemical purity was >99%.
View MoreContact:732.938.2777
Address:5012 Industrial Road Farmingdale, NJ 07727
Contact:86-21-34622192,13917187091,21-34622765
Address:No. 500 Caobao Road Shanghai P.R China
Puyang Huicheng Electronic Material Co., Ltd
website:http://huichengchem.weba.testwebsite.cn/index_en.html
Contact:+86-393-8910800
Address:West Section Shengli Road, Puyang457000, China
Hangzhou Dingyan Chem Co., Ltd
website:http://www.dingyanchem.com
Contact:86-571-87157530-8007
Address:RM.1118,NO.1 Building, Baiyun Tower,Jianggan Area, Hangzhou city, China,310004
Shandong Xiangde Biotechnology Co., Ltd
Contact:+86 -15066639877
Address:Sanba street
Doi:10.1007/BF00903131
(1962)Doi:10.1016/0040-4039(96)01192-6
(1996)Doi:10.1021/jo960852a
(1996)Doi:10.1002/ejoc.201900185
(2019)Doi:10.1021/jacs.0c05917
(2020)Doi:10.1002/zaac.19966220906
(1996)