180847-28-3Relevant articles and documents
Utility of azetidinium methanesulfonates for radiosynthesis of 3-[ 18F]fluoropropyl amines
Kiesewetter, Dale O.,Eckelman, William C.
, p. 953 - 969 (2007/10/03)
3-Methanesulfonyloxypropyl tertiary amines were observed to cyclize to form azetidinium methanesulfonate moieties. Heat-induced cyclization of 3-methanesulfonyloxypropyl amines was utilized for preparation of azetidinium methanesulfonates. The azetidinium methanesulfonates were found to incorporate radioactive [18F]fluoride (decay-corrected yields > 60%) efficiently, resulting in an efficient synthesis of 3-[18F] fluoropropyl tertiary amines. Copyright