176967-62-7

Upstream product

• 161975-39-9 tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate 
• 6457-49-4 4-piperidinemethanol 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 767-00-0 4-cyanophenol 
• 176967-61-6 1-(tert-butoxycarbonyl)-4-(4-cyanophenoxymethyl)piperidine 
• 176967-61-6 1-(tert-butoxycarbonyl)-4-(4-cyanophenoxymethyl)piperidine 

Downstream Products

• 181289-05-4 1-[(3-hydroxypropyl)-4-(4-cyanophenoxymethyl)]piperidine 
• 181289-06-5 3-(4-((4-cyanophenoxy)methyl)piperidin-1-yl)propyl methanesulfonate 
• 877996-17-3 1-(2-methylsulfonyoxylethyl)-4-[(4-cyanophenoxy)methyl]piperidine 
• 180847-28-3 4-{[1-(3-fluoropropyl)-4-piperidinyl]methoxy}benzonitrile 

Relevant academic research and scientific papers

Utility of azetidinium methanesulfonates for radiosynthesis of 3-[ 18F]fluoropropyl amines

3-Methanesulfonyloxypropyl tertiary amines were observed to cyclize to form azetidinium methanesulfonate moieties. Heat-induced cyclization of 3-methanesulfonyloxypropyl amines was utilized for preparation of azetidinium methanesulfonates. The azetidinium methanesulfonates were found to incorporate radioactive [18F]fluoride (decay-corrected yields > 60%) efficiently, resulting in an efficient synthesis of 3-[18F] fluoropropyl tertiary amines. Copyright

Synthesis of 1-(trans-[123I]Iodopropen-2-yl)-4- (4-cyanophenoxymethyl)piperidine: A selective sigma receptor radioligand for SPECT

1-(trans-[123I]Iodopropen-2-yl)-4-(4-cyanophenoxymethyl)piperidine has been prepared as a novel sigma receptor ligand for SPECT. This ligand was round to be selective in vitro for the sigma receptor site (Ki(σ) = 21.7 nM) when tested in a variety of neuroreceptor binding assays. The lipophilicity or this ligand (log P7.5 = 3.36) is appropriate for good brain uptake and relatively low non-specific binding. Radioiodination was accomplished using classical electrophilic iododestannylation methods and Specific activity of the purified product was >2100 mCi/μmole. Radiochemical yields were 60-80% EOS and radiochemical purities were >99%. The average time of synthesis and purification was 35 minutes.