18085-30-8Relevant academic research and scientific papers
Favorskii-like rearrangement of an aliphatic α-halo amide
Kelly, Nicholas M.,Wellejus, Anja,Elbrond-Bek, Heidi,Weidner, Morten Sloth,Jorgensen, Signe Humle
supporting information, p. 1243 - 1249 (2013/04/10)
The reaction of the α-bromoamide 2a with 1-cyclopentylpiperazine gives the Favorskii-like rearranged product 4 when the reaction is heated to 70 °C in a mixture of aqueous potassium hydroxide and ethanol. However, when solid sodium carbonate/potassium iodide is used in ethanol, the nonrearranged product 3a is formed instead. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.
