180853-41-2Relevant articles and documents
Design and synthesis of a cocaine-diamide hapten for vaccine development
Sakurai, Mitsuya,Wirsching, Peter,Janda, Kim D.
, p. 5479 - 5482 (1996)
A cocaine-diamide hapten was designed in an effort to obtain a potent, long-lasting anti-cocaine immune response for the treatment of cocaine abuse. The analogue incorporated an amido linker functionality in place of the carbomethoxy group at C-2 and a benzoylamino replacement of the benzoyloxy group at C-3 of the cocaine framework. Compound 3 was synthesized in 6 chemical steps starting from (+)-2-carbomethoxy-3-tropinone.