180854-45-9

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 180675-03-0 (S)-5-[(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-4-oxa-5-aza-spiro[2.4]heptane-6-carboxylic acid ethyl ester 
• 180675-05-2 (S)-1-[(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-4-oxo-piperidine-2-carboxylic acid ethyl ester 
• 180675-07-4 (2S)-4-oxopiperidine-2-carboxylic acid ethyl ester 
• 180854-44-8 (2S)-N-tert-butoxycarbonyl-4-oxopiperidine-2-carboxylic acid ethyl ester 

Downstream Products

• 125545-98-4 ethyl 2SR-4-oxo-N-(t-butoxycarbonyl)piperidine-2-carboxylate 

Relevant academic research and scientific papers

A new synthesis of (2S)-4-oxopipecolic acid by thermal rearrangement of enantiopure spirocyclopropaneisoxazolidine

A novel synthesis of (2S)-4-oxo-pipecolic acid is reported. The synthetic route employs as a key step the diastereoselective cycloaddition of the N- glycosylnitrone 7 to methylenecyclopropane followed by thermal rearrangement of the spirocyclopropaneisoxazolidine 8a. Stereoselective reduction of the N- BOC methyl ester of 4-oxopipecolic acid by L-selectride gives the protected cis-4-hydroxy-pipecolic acid 14.

Tetrazole excitatory amino acid receptor antagonists

The present invention provides novel tetrazole derivatives useful as excitatory amino acid receptor antagonists and in treating a variety of associated nervous system disorders.