180863-39-2Relevant academic research and scientific papers
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase
Ciccarone, Terrence M.,MacTough, Suzanne C.,Williams, Theresa M.,Dinsmore, Christopher J.,O'Neill, Timothy J.,Shah, Daksha,Culberson, J. Christopher,Koblan, Kenneth S.,Kohl, Nancy E.,Gibbs, Jackson B.,Oliff, Allen I.,Graham, Samuel L.,Hartman, George D.
, p. 1991 - 1996 (2007/10/03)
The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Substitutions on an imidazolylmethyl-AMBA- methionine template gave a highly potent and cell-active inhibitor.
PRODRUGS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
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, (2008/06/13)
The present invention comprises peptidomimetic compounds which comprise a suitably substituted aminoalkylbenzamide moiety. The instant compounds inhibit the farnesyl protein transferase enzyme and the farnesylation of certain proteins. Furthermore, the in
