180869-52-7

Basic information

• Product Name: tert-butyl 4-(4-(4-fluorophenyl)-5-(2-(methylthio)-pyrimidin-4-yl)-1H-imidazol-1-yl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(4-(4-fluorophenyl)-5-(2-(methylthio)-pyrimidin-4-yl)-1H-imidazol-1-yl)piperidine-1-carboxylate
• CAS NO: 180869-52-7
• Molecular Weight: 469.583
• Mol File: 180869-52-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(4-(4-fluorophenyl)-5-(2-(methylthio)-pyrimidin-4-yl)-1H-imidazol-1-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(4-(4-fluorophenyl)-5-(2-(methylthio)-pyrimidin-4-yl)-1H-imidazol-1-yl)piperidine-1-carboxylate(180869-52-7)
• EPA Substance Registry System: tert-butyl 4-(4-(4-fluorophenyl)-5-(2-(methylthio)-pyrimidin-4-yl)-1H-imidazol-1-yl)piperidine-1-carboxylate(180869-52-7)

Safety Data

• Hazardous Substances Data: 180869-52-7(Hazardous Substances Data)

Upstream product

• 165806-95-1 1-((4-fluorophenyl)(isocyano)methylsulfonyl)-4-methylbenzene 
• 1074-68-6 4-formyl-2-(methylthio)pyrimidine 
• 180869-36-7 4-dimethoxymethyl-2-methylsulfanylpyrimidine 

Downstream Products

• 186315-17-3 1-[(1-t-butoxycarbonyl)-4-piperidinyl]-4-(4-fluorophenyl)-5-[(2-methylsulfinyl)pyrimidin-4-yl]imidazole 

Relevant articles and documents

Phenoxypyrimidine inhibitors of p38α kinase: Synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles

As a continuation of our work with 1,4,5 substituted imidazole inhibitors of p38α, we report a series of 1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-phenoxy-4-pyrimidinyl) imidazoles related to 7. The compounds have IC50's for inhibition of p38α ranging from 6.0 to 650 nM. Statistical analysis of the p38α inhibitor potencies shows a correlation of IC50's with the electron donating strength of low molecular weight substituents.

Substituted imidazole compounds

Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.

Substituted imidazole compounds

Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.