18087-62-2

Upstream product

• 96-54-8 N-Methylpyrrole 
• 407-25-0 trifluoroacetic anhydride 
• 75-34-3 1,1-dichloroethane 
• 74-83-9 methyl bromide 
• 2557-70-2 2-(trifluoroacetyl)pyrrole 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 1372129-20-8 C₂₀H₁₉F₃N₂O₃S 
• 13138-78-8 1-methyl-4-nitro-pyrrol-2-carboxylic acid 
• 128887-06-9 1,4-dimethyl-2-trifluoroacetylpyrrole 
• 123136-34-5 1-(1-methyl-2-pyrrolyl)-2,2,2-trifluoroethyl p-nitrobenzoate 

Relevant academic research and scientific papers

Enhancements of Trifluoroacetic Acylated Five-membered Heterocyclic Compounds Using as Additives in Dye Sensitized Solar Cells

In this study, five-membered heterocyclic compounds are trifluoroacetic acylated for the purpose of providing more long pairs to enhance electrolyte in dye sensitized solar cells (DSSCs). Four five-membered heterocyclic compounds will be trifluoroacetic acylated with trifluoroacetic anhydride by Friedel-Crafts acylation: furan, thiophene, pyrrole and N-methylpyrrole. The properties will be measured by cyclic voltage (CV), Fourier transform infrared spectroscopy (FTIR), solar simulator, and electrochemical impedance spectroscopy (EIS). We find out that furan and thiophene which we add in electrolyte as additives can increase short circuit current and photovoltaic efficiency, and furthermore, all the trifluoroacetic acylated heterocyclic compounds perform better photoelectric abilities than non-trifluoroacetic acylated one. The photovoltaic efficiency will be increased from 4.439% to 5.197% when 1wt% trifluoroacetic acylated thiophene is added in electrolyte as additives.

Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

Polyamides-based compounds related to the Streptomycetal distamycin and netropsin are potent cytostatic molecules that bind to AT-rich regions of the minor groove of the DNA, hence interfering with DNA replication and transcription. Recently, derivatives belonging to this scaffold have been reported to halt the proliferation of deadly African trypanosomes by different and unrelated mechanisms. Here we describe the synthesis and preliminary characterization of the anti-trypanosomal mode of action of new potent and selective distamycin analogues. Two tri-heterocyclic derivatives containing a central N-methyl pyrrole ring (16 and 17) displayed high activity (EC50 5000 with respect to mammalian macrophages) against the infective form of T. brucei. Both compounds caused cell cycle arrest by blocking the replication of the mitochondrial DNA but without affecting its integrity. This mode of action clearly differs from that reported for classical minor groove binder (MGB) drugs, which induce the degradation of the mitochondrial DNA. In line with this, in vitro assays suggest that 16 and 17 have a comparatively lower affinity for different template DNAs than the MGB drug diminazene. Therapeutic efficacy studies and stability assays suggest that the pharmacological properties of the hits should be optimized. The compounds can be rated as excellent scaffolds for the design of highly potent and selective anti-T. brucei agents.

The synthesis of diarylsulfones with simple arenes and K2S2O8 through double C-S bond formation

An unprecedented double C-S bond formation method has been developed to prepare both symmetric and unsymmetric diarylsulfones with simple arenes in a single step. This represents the first example that K2S2O8 can be employed as a highly effective sulfonating agent to synthesize diarylsulfones. The reaction demonstrates excellent reactivity, good functional group tolerance and high yields.

Discovery of a new binding mode for a series of liver X receptor agonists

Structural modification of a series of dual LXRα/β agonists led to the identification of a new class of LXRβ partial agonists. An X-ray co-crystal structure shows that a representative member of this series, pyrrole 5, binds to LXRβ with a reversed orient

Formation and reactivvity of 1-pyrrolyl-2,2,2-trifluoroethyl cations

1-(1-Methyl-2-pyrrolyl)-2,2,2-trifluoroethyl p-nitrobenzoate (3) reacts by carbocation formation with an m value for the dependence of rate on the solvent polarity parameter YOTs of 0.56, and a rate 41 times slower than (1-methyl-2-pyrrolyl) me

SOLVOLYTIC REACTIVITY OF 1-(1-METHYL-2-PYRROLYL)-2,2,2-TRIFLUOROETHYL p-NITROBENZOATE

1-(1-Methyl-2-pyrrolyl)-2,2,2-trifluoroethyl p-nitrobenzoate (1) solvolyses to form a carbocation intermediate 4 as evidenced by the dependence on the solvent ionizing power YOTs and the formation of substitution products.The rate ratio k(H)/k(CF3) of only 40 indicates strong electron donation to the destabilized carbocation.

Aryltrifluoroethylamines

Certain arylmethyl amines have been prepared wherein the "methyl" carbon is substituted with a polyfluoroalkyl radical. The compounds form acid addition salts, exist in resolvable stereoisomeric forms, and are useful for treating hypertension. Formulations for human and veterinary medicine are described, as well as methods of use.

Products from N-Substituted Pyrroles and Trifluoroacetic Anhydride: Ratios and Conformations of Isomers

A series of N-substituted pyrroles has been treated with trifluoroacetic anhydride.Small alkyl groups or aryl groups (as the N-substituents) lead exclusively, or almost exclusively, to the 2-trifluoroacetyl derivatives, bulky groups (notably 1-adamantyl) to the 3-derivatives, and those of intermediate size (such as i-propyl) to mixtures of isomers.N-Substituted 3-trifluoroacetylpyrroles exist in solution as mixtures of rotational isomers whereas the 2-isomers adopt a preferred conformation in which the nitrogen and oxygen atoms are in the syn orientation.