123136-34-5

Upstream product

• 70783-51-6 1-(N-methyl-1H-pyrrole-2-yl)-2,2,2-trifluoroethan-1-ol 
• 122-04-3 4-nitro-benzoyl chloride 
• 96-54-8 N-Methylpyrrole 
• 18087-62-2 2,2,2-trifluoro-1-(1-methyl-1H-pyrrol-2-yl)ethan-1-one 

Downstream Products

• 130719-83-4 1-methyl-2-(2,2,2-trifluoroethyl)-5-ethoxypyrrole 
• 130719-81-2 1-(1-methyl-2-pyrrolyl)-2,2,2-trifluoroethyl ethyl ether 

Relevant academic research and scientific papers

SOLVOLYTIC REACTIVITY OF 1-(1-METHYL-2-PYRROLYL)-2,2,2-TRIFLUOROETHYL p-NITROBENZOATE

1-(1-Methyl-2-pyrrolyl)-2,2,2-trifluoroethyl p-nitrobenzoate (1) solvolyses to form a carbocation intermediate 4 as evidenced by the dependence on the solvent ionizing power YOTs and the formation of substitution products.The rate ratio k(H)/k(CF3) of only 40 indicates strong electron donation to the destabilized carbocation.

Formation and reactivvity of 1-pyrrolyl-2,2,2-trifluoroethyl cations

1-(1-Methyl-2-pyrrolyl)-2,2,2-trifluoroethyl p-nitrobenzoate (3) reacts by carbocation formation with an m value for the dependence of rate on the solvent polarity parameter YOTs of 0.56, and a rate 41 times slower than (1-methyl-2-pyrrolyl) me