18087-76-8

Usage

Uses

Used in Pharmaceutical Industry:
6-CHLORO-3-NITRO-IMIDAZO[1,2-B]PYRIDAZIN is used as an intermediate in the synthesis of various pharmaceuticals for its antimicrobial and antiparasitic properties. Its unique structure allows for the development of new drugs targeting a wide range of infections and diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 6-CHLORO-3-NITRO-IMIDAZO[1,2-B]PYRIDAZIN is used as a key component in the production of pesticides and other agrochemicals. Its antimicrobial properties make it effective in controlling pests and diseases in crops, thereby enhancing agricultural productivity.
Used in Drug Development:
6-CHLORO-3-NITRO-IMIDAZO[1,2-B]PYRIDAZIN is utilized as a building block in drug development, where its reactive nature allows for the creation of novel compounds with potential therapeutic applications. Its versatility in chemical reactions enables the design of new drugs with improved efficacy and reduced side effects.
Used in Medical Research:
In the field of medical research, 6-CHLORO-3-NITRO-IMIDAZO[1,2-B]PYRIDAZIN serves as a valuable compound for studying the mechanisms of action of antimicrobial and antiparasitic agents. Its unique structure provides insights into the development of new therapeutic strategies and the understanding of drug resistance patterns in various pathogens.

InChI:InChI=1/C6H3ClN4O2/c7-4-1-2-5-8-3-6(11(12)13)10(5)9-4/h1-3H

Upstream product

• 6775-78-6 6-chloroimidazo[1,2-b]pyridazine 

Downstream Products

• 37990-33-3 6-amino-3-nitroimidazo[1,2-b]pyridazine 
• 166176-50-7 3,6-diaminoimidazo[1,2-b]pyridazine 
• 316123-93-0 6-amino-3-bis(phenoxycarbomyl)aminoimidazo[1,2-b]pyridazine 
• 923595-94-2 3-nitro-N-[(1S)-1-phenylethyl]imidazo[1,2-b]pyridazin-6-amine 
• 1150567-42-2 (4-fluoro-benzyl)-(3-nitro-imidazo[1,2-b]pyridazin-6-yl)-amine 
• 1150567-36-4 3-nitro-6-phenyl-imidazo[1,2-b]pyridazine 
• 1150567-88-6 (3,4-dichloro-benzyl)-methyl-(3-nitro-imidazo[1,2-b]pyridazin-6-yl)-amine 
• 1150567-52-4 3-nitro-6-phenoxy-imidazo[1,2-b]pyridazine 
• 1365214-38-5 ethyl N-{6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl}carbamate 
• 1365214-54-5 (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-amine 
• 1365214-20-5 ({6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl}carbamoyl)methyl acetate 
• 1365214-19-2 2-ethoxy-N-{6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl}acetamide 
• 1218935-63-7 6-(2-(3-fluorophenyl)piperidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine 
• 1218935-61-5 (R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine 

Relevant academic research and scientific papers

Synthesis method of 3-nitro-6- chloroimidazo[1,2-b] pyridazine

The invention relates to a synthesis method of 3-nitro-6-chloroimidazo[1,2-b] pyridazine. 3-amino-6-chloropyridazine, chloroacetaldehyde water solution and nitric acid are used as raw materials; the mol ratio of the 3-amino-6-chloropyridazine to the 40-percent chloroacetaldehyde water solution is 1:(1.0 to 2.3); the mol ratio of the 3-amino-6-chloropyridazine to the nitric acid is 1:(1.2 to 6.0); in a proper solvent, under the effect of alkali, the reaction is continuously performed at 0 to 90 DEG C for 6 to 12 hours to generate a coarse product of the 3-nitro-6-chloroimidazo[1,2-b] pyridazine; after the purification, a pure product of the 3-nitro-6-chloroimidazo[1,2-b] pyridazine is obtained. The method provided by the invention has the advantages that the raw materials can be easily obtained; the price is reasonable; meanwhile, in the preparation reaction, heavy metal and corrosion gas are not used; the reaction is mild; no special requirements exist on the reaction equipment; the production can be performed by ordinary anti-corrosion equipment; in addition, the reaction conditions of the method are proper.

COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.

SUBSTITUTED IMIDAZO[1,2B]PYRIDAZINE COMPOUNDS AS TRK KINASE INHIBITORS

Compounds of Formula (I): in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor.

IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS

There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protei kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer.

Synthetic studies on condensed-azole derivatives. IV. Synthesis and anti-asthmatic activities of ω-sulfamoylalkyloxyimidazo[1,2-b]pyridazines

A series of novel (imidazo[1,2-b]pyridazin-6-yl)oxyalkylsulfonamides was synthesized and evaluated for the ability to inhibit platelet activating factor (PAF)-induced bronchoconstriction in guinea pigs. The compounds bearing a gem-dialkyl or a cycloalkylidene group at the 2 position of the sulfamoylpropyloxy group in the side chain were found to have potent activity. Among them, 3-(imidazo[1,2-b]pyridazin-6-yl)oxy-2,2-dimethylpropanesulfonamide (6) showed excellent anti-asthmatic activity and the longest duration of action. The compounds bearing a methyl group at the 7 or 8 position of the imidazo[1,2-b]pyridazine ring were found to have enhanced activity. Among them, 3-(7-methylimidazo[1,2-b]pyridazin-6-yl)oxy-2,2-dimethylpropanesulfonamide (25) showed the most potent inhibitory effect, and its anti-asthmatic effect in an experimental model of allergic asthma was superior to that of theophylline. The structure-activity relationships in this series of compounds are discussed.