180900-28-1

Basic information

• Product Name: 3-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-3-oxo-propionic acid ethyl ester
• CAS NO: 180900-28-1
• Molecular Weight: 434.489
• Mol File: 180900-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-3-oxo-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-3-oxo-propionic acid ethyl ester(180900-28-1)
• EPA Substance Registry System: 3-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-3-oxo-propionic acid ethyl ester(180900-28-1)

Safety Data

• Hazardous Substances Data: 180900-28-1(Hazardous Substances Data)

Upstream product

• 19859-90-6 [3,5-bis(benzyloxy)-4-methoxyphenyl]methanol 

Downstream Products

• 180900-48-5 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol 
• 180900-32-7 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione 
• 19859-90-6 [3,5-bis(benzyloxy)-4-methoxyphenyl]methanol 
• 180900-30-5 2-(3,5-Bis-benzyloxy-4-methoxy-benzoyl)-4-oxo-4-(3,4,5-trimethoxy-phenyl)-butyric acid ethyl ester 

Relevant articles and documents

Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.