180900-48-5

Basic information

• Product Name: 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol
• Synonyms: 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol
• CAS NO: 180900-48-5
• Molecular Weight: 574.671
• Mol File: 180900-48-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol(180900-48-5)
• EPA Substance Registry System: 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol(180900-48-5)

Safety Data

• Hazardous Substances Data: 180900-48-5(Hazardous Substances Data)

Upstream product

• 180900-30-5 2-(3,5-Bis-benzyloxy-4-methoxy-benzoyl)-4-oxo-4-(3,4,5-trimethoxy-phenyl)-butyric acid ethyl ester 
• 180900-28-1 3-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-3-oxo-propionic acid ethyl ester 
• 19859-89-3 3,5-bis(benzyloxy)-4-methoxybenzoyl chloride 
• 19859-90-6 [3,5-bis(benzyloxy)-4-methoxyphenyl]methanol 
• 180900-32-7 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione 

Relevant articles and documents

Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.