180904-58-9Relevant academic research and scientific papers
Synthesis of new 2-substituted-[1,3,4]-oxadiazino-[5,6-b]-indoles with H1-antihistaminic, antimuscarinic and antimicrobial activity
Ajitha,Rajnarayana,Sarangapani
, p. 796 - 799 (2007/10/03)
New 2-substituted-[1,3,4]-oxadiazino-[5,6-b]-indoles have been prepared and tested for their antibacterial, antifungal, H1-anti-histaminic and antimuscarinic activities. Among them, compounds 5b, 5d, 5k exhibited higher H1-antihistaminic activity than pheniramine maleate. Compounds 5c, 5d showed higher antibacterial activity than ampicillin against Staphylococcus aureus and E. coli, respectively.
Some 3-hydrazono-2-indolinones and N-Mannich bases as potential anticonvulsants
Gursoy,Karali,Buyuktimkin,Demirayak,Ekinci,Ozer
, p. 437 - 442 (2007/10/03)
In this study a new series of 3-aryloxy/arylthioxyacetylhydrazono-2- indolinones obtained by condensation of isatin with aryloxy/arythioxyacetylhydrazines were treated with morpholine and formaldehyde to yield 1-morpholinomethyl-3-aryloxy/arylthioxyacetylhydrazono-2-indolino nes. Structures of all the compounds were assigned on the basis of spectral data (UV, IR, 1H-NMR, EIMS) and elemental analyses. Anticonvulsant evaluation of the compounds revealed varying degrees of activity against pentylenentetrazole induced seizures.
