180906-52-9

Upstream product

• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 
• 756-79-6 dimethyl methane phosphonate 
• 128478-99-9 methylphosphonic acid dimethyl ester; deprotonated form 

Downstream Products

• 180906-51-8 dimethyl (2R)-β-amino-β-phenylethylphosphonate 

Relevant academic research and scientific papers

A highly efficient asymmetric synthesis of β-aminophosphonic acids via addition of α-phosphonate carbanions to chiral, enantiopure sulfinimines

Addition of α-phosphonate carbanions to (S)-sulfinimines 1 affords N-sulfinyl β-aminophosphonates 2 in a diastereoisomeric ratio from 5:1 to 10:1; the major diastereoisomers of 2, after separation, are converted to the corresponding β-aminophosphonates 3

A New Asymmetric Synthesis of β-Aminophosphonic Acids

Addition of α-phosphonate carbanions to (S)-sulfinimines 2 gives N-sulfinyl-β-aminophosphonates 3 with a high diastereoselectivity (up to 10:1).The major diastereometer of 3 (R=Ph) was converted into (+)-(R)-β-amino-β-phenylethanephosphonic acid 5. - Keyw