A highly efficient asymmetric synthesis of β-aminophosphonic acids via addition of α-phosphonate carbanions to chiral, enantiopure sulfinimines

DOI: 10.1039/CC9960001503

Source and publish data:

Chemical Communications p. 1503 - 1504 (1996)

Update date:2022-08-03

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Authors:

Mikolajczyk, Marian

Lyzwa, Piotr

Drabowicz, Jozef

Wieczorek, Michal W.

Blaszczyk, Jaroslaw

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Article abstract of DOI:10.1039/CC9960001503

Addition of α-phosphonate carbanions to (S)-sulfinimines 1 affords N-sulfinyl β-aminophosphonates 2 in a diastereoisomeric ratio from 5:1 to 10:1; the major diastereoisomers of 2, after separation, are converted to the corresponding β-aminophosphonates 3

Full text of DOI:10.1039/CC9960001503

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