180915-77-9

Basic information

• Product Name: (R)-6-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE
• Synonyms: (R)-6-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE;(R)-6-METHOXY-INDAN-1-YLAMINE;(1R)-6-Methoxy-2,3-dihydro-1H-inden-1-aMine
• CAS NO: 180915-77-9
• Molecular Formula: C10H13NO
• Molecular Weight: 163.22
• Mol File: 180915-77-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-6-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-6-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE(180915-77-9)
• EPA Substance Registry System: (R)-6-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE(180915-77-9)

Safety Data

• Hazardous Substances Data: 180915-77-9(Hazardous Substances Data)

Usage

General Description

"(R)-6-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE" is a chemical compound that belongs to the class of amines. It is a chiral molecule, meaning it has a non-superimposable mirror image, and the (R) prefix in its name denotes its stereochemistry. The presence of a methoxy group and a dihydroindene moiety in its structure indicates its potential use in pharmaceutical and organic synthesis. It may have applications in medicinal chemistry, as well as in the synthesis of other complex organic molecules. (R)-6-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE's distinct structure and properties make it a valuable building block for the synthesis of various drugs and biologically active compounds.

Upstream product

• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 180915-76-8 6-methoxyindan-1-one oxime 
• 3469-07-6 5-methoxy-1H-indene 
• 64-19-7 acetic acid 

Downstream Products

• 169105-03-7 (R)-6-Hydroxy-1-aminoindan.HCl 
• 133497-57-1 1-amino-6-hydroxyindan 

Relevant articles and documents

Deconstructive Oxygenation of Unstrained Cycloalkanamines

A deconstructive oxygenation of unstrained primary cycloalkanamines has been developed for the first time using an auto-oxidative aromatization promoted C(sp3)?C(sp3) bond cleavage strategy. This metal-free method involves the substitution reaction of cycloalkanamines with hydrazonyl chlorides and subsequent auto-oxidative annulation to in situ generate pre-aromatics, followed by N-radical-promoted ring-opening and further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines, and peptides, as well as steroids.

Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates

A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the presence of an organic anhydride with subsequent hydrolysis is described. The process is commercially feasible providing indanylamine and aminotetralin derivatives in high yield that are useful as intermediates in the production of therapeutically active compounds. Also described are novel intermediates, 1-indanone O-acetyl oximes and 1-tetralone O-acetyl oximes.

Process for the synthesis of substituted alpha-aminoindan derivatives

A process for the preparation of optically active substituted alpha-indanyl amide derivatives of formula (I), which comprise:an asymmetric hydrogenation reaction of an en-amide derivative of formula (III) in presence of hydrogen and an optically active catalyst, in order to obtain an amide derivative of formula (II),a hydrolysis reaction of the amide derivative of formula (II) obtained in the previous step, in order to obtain optically active substituted alpha-indanyl amide derivatives of formula (I).