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119-81-3

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  • 4'-methoxy-2'-nitroacetanilide;2-nitro-p-acetanisidid;n-(4-methoxy-2-nitrophenyl)-acetamid;Esomeprazole Sodium Impurity 32;p-Acetaniside, 2'-nitro-;p-Acetanisidide,

    Cas No: 119-81-3

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  • Hangzhou Sartort Biopharma Co., Ltd
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119-81-3 Usage

Uses

Different sources of media describe the Uses of 119-81-3 differently. You can refer to the following data:
1. Like Methacetin (M258770) derivative, N-(4-Methoxy-2-nitrophenyl)acetaMide can be used in the synthesis of a Thiabendazole
2. Methacetin (M258770) derivative. Used in the synthesis of a Thiabendazole (T344150) metabolite.

Check Digit Verification of cas no

The CAS Registry Mumber 119-81-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 119-81:
(5*1)+(4*1)+(3*9)+(2*8)+(1*1)=53
53 % 10 = 3
So 119-81-3 is a valid CAS Registry Number.

119-81-3 Well-known Company Product Price

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  • Alfa Aesar

  • (L04218)  4'-Methoxy-2'-nitroacetanilide, 98+%   

  • 119-81-3

  • 5g

  • 376.0CNY

  • Detail
  • Alfa Aesar

  • (L04218)  4'-Methoxy-2'-nitroacetanilide, 98+%   

  • 119-81-3

  • 25g

  • 1504.0CNY

  • Detail

119-81-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-METHOXY-2-NITROACETANILIDE

1.2 Other means of identification

Product number -
Other names N-(4-Methoxy-2-nitrophenyl)acetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:119-81-3 SDS

119-81-3Synthetic route

4-methoxyacetanilide
51-66-1

4-methoxyacetanilide

A

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

B

p-benzoquinone
106-51-4

p-benzoquinone

Conditions
ConditionsYield
With nitric acid; silica gel In dichloromethane for 0.166667h; Product distribution; Ambient temperature;A 97%
B 2%
4-methoxyacetanilide
51-66-1

4-methoxyacetanilide

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
With 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imide at 20℃; for 6h; Ionic liquid;94%
With sulfuric acid; nitric acid at 0 - 5℃;91%
With nitric acid In dichloromethane at 20℃; for 2h; Heating / reflux;90%
acetic anhydride
108-24-7

acetic anhydride

4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
With bismuth (III) nitrate pentahydrate In dichloromethane at 23℃; regioselective reaction;86%
Stage #1: acetic anhydride; 4-methoxy-aniline With acetic acid In water at 0 - 5℃;
Stage #2: With sulfuric acid In water at 60 - 65℃; for 0.166667h; Cooling with ice;
acetic anhydride
108-24-7

acetic anhydride

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
for 0.00277778h; Green chemistry;78%
With sulfuric acid Heating;
4-acetylaminomethoxybenzene

4-acetylaminomethoxybenzene

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
With nitric acid; acetic anhydride; acetic acid In water75%
methanol
67-56-1

methanol

Acetanilid
103-84-4

Acetanilid

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; nitric acid; bis-[(trifluoroacetoxy)iodo]benzene In water at 40℃; for 0.5h;53%
N-(4-methoxyphenyl)-N'-methylurea
21260-49-1

N-(4-methoxyphenyl)-N'-methylurea

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
With nitric acid In acetic acid for 0.333333h; Ambient temperature;30%
acetic anhydride
108-24-7

acetic anhydride

4-methoxy-aniline
104-94-9

4-methoxy-aniline

acetic acid
64-19-7

acetic acid

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
at 20℃; anschliessendes Behandeln mit Salpetersaeure in Essigsaeure unterhalb 15grad;
4-methoxy-N-nitrosoacetanilide
14839-81-7

4-methoxy-N-nitrosoacetanilide

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
In tetrachloromethane at 33℃; for 0.733333h;0.8 % Chromat.
nitric acid
7697-37-2

nitric acid

4-methoxyacetanilide
51-66-1

4-methoxyacetanilide

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

nitric acid
7697-37-2

nitric acid

4-methoxyacetanilide
51-66-1

4-methoxyacetanilide

acetic acid
64-19-7

acetic acid

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / acetic acid / 2 h / 110 °C
2: 91 percent / nitric acid; sulfuric acid / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid
2: nitric acid; acetic acid
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane
2: nitric acid; acetic anhydride / dichloromethane
View Scheme
4-methoxy-aniline
104-94-9

4-methoxy-aniline

p-azoanisole

p-azoanisole

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid / 0.25 h / Heating
2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min
View Scheme
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
ConditionsYield
With potassium hydroxide; sodium hydroxide In water for 0.5h; Heating;99%
With hydrogenchloride; water In ethanol for 6h; Reflux; Inert atmosphere;98%
With hydrogenchloride In water for 18h; Reflux;97.9%
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

2-nitro-4-methoxybenzene diazonium tetrafluoroborate

2-nitro-4-methoxybenzene diazonium tetrafluoroborate

Conditions
ConditionsYield
Stage #1: 4-methoxy-2-nitroacetanilide With boron trifluoride - methanol (1/1) In methanol at 60℃; Inert atmosphere; Reflux;
Stage #2: With tert.-butylnitrite In methanol at -15℃; Inert atmosphere;
92%
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

2'-amino-p-acetanisidide
5472-37-7

2'-amino-p-acetanisidide

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol91%
With hydrogen; palladium on activated charcoal In ethanol under 2585.7 Torr; for 2.5h;80%
With ethanol; platinum Hydrogenation;
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

6-methoxy-2-methyl-1H-benzo[d]imidazole
4887-81-4

6-methoxy-2-methyl-1H-benzo[d]imidazole

Conditions
ConditionsYield
With iron; acetic acid at 60℃; for 0.5h;84%
methanol
67-56-1

methanol

4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
ConditionsYield
With potassium hydroxide
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

4-methoxy-2-nitrophenol
1568-70-3

4-methoxy-2-nitrophenol

Conditions
ConditionsYield
With sodium hydroxide
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

3,4-dinitroanisole
4280-28-8

3,4-dinitroanisole

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

N-(4-methoxy-2-nitro-phenyl)-thioacetamide
65183-00-8

N-(4-methoxy-2-nitro-phenyl)-thioacetamide

Conditions
ConditionsYield
With potassium sulphide; phosphorous (V) sulfide; benzene
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

acetic acid-(4-methoxy-N-methyl-2-nitro-anilide)
85020-96-8

acetic acid-(4-methoxy-N-methyl-2-nitro-anilide)

Conditions
ConditionsYield
With sodium; benzene anschliessendes Behandeln mit Dimethylsulfat;
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

acetic acid-(4-methoxy-2,3-dinitro-anilide)
62153-30-4

acetic acid-(4-methoxy-2,3-dinitro-anilide)

Conditions
ConditionsYield
With nitric acid
With nitric acid; acetic acid
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

acetic acid
64-19-7

acetic acid

2'-amino-p-acetanisidide
5472-37-7

2'-amino-p-acetanisidide

Conditions
ConditionsYield
With iron
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

2-(diethylamino)ethyl chloride
100-35-6

2-(diethylamino)ethyl chloride

acetic acid-[N-(2-diethylamino-ethyl)-4-methoxy-2-nitro-anilide]

acetic acid-[N-(2-diethylamino-ethyl)-4-methoxy-2-nitro-anilide]

Conditions
ConditionsYield
With sodium amide; toluene
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

glycerol
56-81-5

glycerol

6-methoxy-8-nitroquinoline
85-81-4

6-methoxy-8-nitroquinoline

Conditions
ConditionsYield
With sulfuric acid; orthoarsenic acid at 140℃;
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

urethane
51-79-6

urethane

5-methoxy-benzo[1,2,5]oxadiazole
4413-48-3

5-methoxy-benzo[1,2,5]oxadiazole

Conditions
ConditionsYield
With phosphorus pentoxide; xylene
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

benzene
71-43-2

benzene

4-methoxy-2-nitro-1,1'-biphenyl
16098-16-1

4-methoxy-2-nitro-1,1'-biphenyl

Conditions
ConditionsYield
(i) NO, NaOAc, (ii) /BRN= 969212/; Multistep reaction;
(i) N2O4, NaOAc, AcOH, Ac2O, (ii) /BRN= 969212/; Multistep reaction;
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

4-methoxy-N1-ethylbenzene-1,2-diamine
79938-45-7

4-methoxy-N1-ethylbenzene-1,2-diamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 1h;472 mg
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

methyl iodide
74-88-4

methyl iodide

acetic acid-(4-methoxy-N-methyl-2-nitro-anilide)
85020-96-8

acetic acid-(4-methoxy-N-methyl-2-nitro-anilide)

Conditions
ConditionsYield
With potassium hydroxide In acetone for 0.5h; Heating; Yield given;
In N-methyl-acetamide; ethyl acetate
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

2-bromo-4-methoxy-6-nitrobenzenamine
10172-35-7

2-bromo-4-methoxy-6-nitrobenzenamine

Conditions
ConditionsYield
(i) aq. KOH, MeOH, (ii) Br2, AcOH; Multistep reaction;
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

2,3,4,5-tetrabromoanisole
6161-61-1

2,3,4,5-tetrabromoanisole

Conditions
ConditionsYield
With pyridine; bromine; acetic acid
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

acetic acid-(4-methoxy-2,6-dinitro-anilide)

acetic acid-(4-methoxy-2,6-dinitro-anilide)

Conditions
ConditionsYield
With sulfuric acid; nitric acid 1.) 0 deg C, 10 min, 2.) RT, 30 min;

119-81-3Relevant articles and documents

Fused tricyclic derivative as FGFR4 inhibitor

-

Paragraph 0597-0602, (2021/05/12)

The present invention provides a fused tricyclic derivative that is the selective inhibitor of fibroblast growth factor receptor 4 (FGFR4), a pharmaceutical composition containing the compound, a method of making the compound and a method of treating cell proliferative diseases, such as cancer, using the compounds of the invention.

Method for synthesizing 4-methoxy-2-nitroaniline by adopting continuous flow reactor

-

, (2020/10/05)

The invention relates to the technical field of organic synthesis, and discloses a method for synthesizing 4-methoxy-2-nitroaniline by using a continuous flow reactor. The method comprises the following steps: S1, respectively adding a 4-methoxyaniline solution and acetic anhydride into a continuous flow reactor I, and carrying out an acetylation reaction to obtain a reaction solution I containing4-methoxyacetanilide; S2, respectively adding a nitration reagent and the reaction solution I into a continuous flow reactor II, and carrying out a nitration reaction to obtain a reaction solution IIcontaining 4-methoxy-2-nitroacetanilide; S3, respectively adding hydrolysate and the reaction solution II into a continuous flow reactor III, and carrying out a hydrolysis reaction to obtain a reaction solution III containing 4-methoxy-2-nitroaniline; and S4, carrying out post-treatment on the reaction solution III to obtain 4-methoxy-2-nitroaniline. The method is high in reaction speed, small inamount of byproduct 4-methoxy-3-nitroaniline, high in heat and mass transfer efficiency, high in reaction safety, high in selectivity, high in yield and purity and convenient in after-treatment.

Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation

Wan, Yameng,Zhang, Zhiguo,Ma, Nana,Bi, Jingjing,Zhang, Guisheng

, p. 780 - 791 (2019/01/24)

Novel acylamino-directed relay disubstitutions realize the sequential difunctionalizations of anilides (1) under mild and metal-free conditions for the first time. This [bis(trifluoroacetoxy)iodo]benzene (PIFA) and BF3·Et2O promoted straightforward reaction produces a series of p-acetoxyl- or p-alkoxyl-o-nitro-N-arylamides (2), which are key scaffolds of various drugs, functional materials, and bioactive molecules. The flexibility with respect to the functional groups in these products affords this novel protocol excellent versatility for synthetic applications.

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