180923-77-7

Basic information

• Product Name: (2S)-3-Methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoic acid
• Synonyms: (2S)-3-Methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoic acid;(S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoic acid(WX142530);(S)-3-METHYL-2-(1-OXOISOINDOLIN-2-YL)BUTANOIC ACID
• CAS NO: 180923-77-7
• Molecular Formula: C13H15NO3
• Molecular Weight: 233.2631
• EINECS: 939-914-8
• Mol File: 180923-77-7.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S)-3-Methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-3-Methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoic acid(180923-77-7)
• EPA Substance Registry System: (2S)-3-Methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoic acid(180923-77-7)

Safety Data

• Hazardous Substances Data: 180923-77-7(Hazardous Substances Data)

Usage

General Description

The chemical "(2S)-3-Methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoic acid" is a compound with the molecular formula C15H17NO4. It is a derivative of the amino acid leucine, and it is classified as a dihydroisoindole compound. It is a white solid at room temperature and is sparingly soluble in water. This chemical may have potential applications in pharmaceuticals and as a building block for the synthesis of other organic compounds. Further research and study are needed to fully understand its properties, uses, and potential benefits.

Upstream product

• 640-68-6 D-Val-OH 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 72-18-4 L-valine 

Downstream Products

• 1448188-69-9 (2S,4R)-4-hydroxy-N-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl]-1-[(2S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl]pyrrolidine-2-carboxamide 
• 1448188-71-3 (2S,4R)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl) benzyl)-1-((R)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide 

Relevant articles and documents

BIFUNCTIONAL COMPOUNDS

The invention provides a bifunctional compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein said Targeting Ligand, Linker and Degron are as described herein.

EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of receptor tyrosine kinase (RTK) proteins. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand which binds to an E3 ubiquitin ligase and on the other end a moiety which binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effectuate ubiquitination, and therefore, degradation (and inhibition) of the target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.