18093-85-1Relevant academic research and scientific papers
Novel 5-(1-aryl-1H-pyrazol-3-yl)-1H-tetrazoles as glycogen phosphorylase inhibitors: An in vivo antihyperglycemic activity study
Kattimani, Pramod P.,Somagond, Shilpa M.,Bayannavar, Praveen K.,Kamble, Ravindra R.,Bijjaragi, Subhas C.,Hunnur, Raveendra K.,Joshi, Shrinivas D.
, p. 70 - 84 (2020)
In this study, we report the ring transformation of 3-arylsydnone into 1-aryl-1H-pyrazole-3-carbonitriles via [3 + 2] cycloaddition with acrylonitrile. 1-Aryl-1H-pyrazole-3-carbonitrile underwent [2 + 3] cycloaddition with sodium azide to afford 5-(1-aryl-1H-pyrazol-3-yl)-1H-tetrazoles which were further subjected to N-alkylation with aryl/heteroaryl alkyl halides to afford 1,5- and 2,5-disubstituted tetrazoles. Furthermore, the title compounds were screened for in vivo antihyperglycemic activity using albino Wistar rats of either sex. Compounds 4a, 6b, 7a, 7b, 8b, and 9b showed maximum fall in the blood glucose levels in streptozotocin-induced diabetic rats after 5–7 days of administration. In support of antidiabetic activity, we also performed the experimental in vivo studies, namely, effect of compounds on enzymes (serum glutamic oxaloacetic transaminase, serum glutamic-pyruvic transaminase, creatinine, urea, and total protein), antihyperlipidemic, and histopathology. Moreover, the molecular docking study has been performed for potent molecules among the series with glycogen phosphorylase as target enzyme, and this study corroborated the experimental in vivo results.
Novel pyrazole derivatives via ring transformations: Anti-inflammatory and antifungal activity studies
Dodamani, Suneel S.,Jalalpure, Sunil S.,Joshi, Shrinivas D.,Kamble, Ravindra R.,Kariduraganavar, Mahadevappa Y.,Kattimani, Pramod P.,Nesaragi, Aravind R.
supporting information, p. 3125 - 3140 (2021/09/11)
In this paper, the synthesis of novel pyrazoles and their in vitro anti-inflammatory and in-vitro antifungal assay have been reported. These compounds were docked into the inducible nitric oxide synthase (iNOS) oxygenase dimer. The compounds 3c, 7a, 7c, 8
1,3-Dipolar cycloadditions of silicon and tin alkynes and alkenes. Regiospecific synthesis of silyl and stannylpyrazoles and pyrazolines
González-Nogal, Ana M.,Calle, Mariola,Cuadrado, Purificación,Valero, Raquel
, p. 224 - 231 (2007/10/03)
Silicon and tin 3-, 3,5-, and 3,4,5-metalated pyrazoles have been synthesized by 1,3-dipolar cycloadditions of silyl-, disilyl-, and silylstannylacetylenes with N-phenylsydnone or trimethylsilyldiazomethane. On the other hand, 1- and 2-pyrazolines monomet
Solvent-free preparation of tris-pyrazolyl-1,3,5-triazines
De La Hoz, Antonio,Díaz-Ortiz, Angel,Elguero, José,Martínez, Luis J.,Moreno, Andrés,Sánchez-Migallón, Ana
, p. 4397 - 4403 (2007/10/03)
Tris-pyrazolyl-1,3,5-triazines have been prepared by cyclotrimerization of aromatic nitriles in solvent-free conditions. The interesting structures of these compounds make them candidates for application in coordination chemistry and crystal engineering.
