180959-07-3

Upstream product

• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 181140-34-1 (-)-2-[(2R)-oxiran-2-ylmethyl]-1H-isoindole-1,3(2H)-dione 
• 136918-14-4 phthalimide 

Downstream Products

• 180959-13-1 (R)-(-)-3-?(4-(2-methoxyphenyl)piperazin-1-yl)methyl-5-methylthio-2,3-dihydroimidazo[1,2-c]quinazoline 
• 180959-11-9 (R)-1-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-3-(2-methylsulfanyl-quinazolin-4-ylamino)-propan-2-ol 
• 180959-09-5 (R)-(-)-1-amino-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-2-ol 

Relevant academic research and scientific papers

Studies on quinazolines. 6. Asymmetric synthesis of (S)-(+)- and (R)-(-)-3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-5-methylthio-2,3- dihydroimidazo[1,2-c]quinazolines

The titled compounds have been synthesized in five steps from commercially available (R)-(+) and (S)-(-)-glycidol. The overall yield was about 29% with ee>98.5%. Copyright