18096-82-7

Upstream product

• 1003-67-4 4-methylpyridine-1-oxide 
• 120-21-8 4-Diethylaminobenzaldehyde 
• 100-43-6 4-vinylpyridine 
• 2052-06-4 4-bromo-N,N-diethylaniline 
• 108-89-4 picoline 
• 459-57-4 4-fluorobenzaldehyde 
• 57702-49-5 N,N-diethyl-4-iodo-aniline 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 139619-04-8 1-(carbethoxymethyl)-4-pyridinium bromide 
• 1123207-45-3 Br^(1-)*C₇₀H₆₅N₈O₂⁽¹⁺⁾ 
• 105802-46-8 4-{(E)-2-[4-(diethylamino)phenyl]ethenyl}-1-methylpyridinium iodide 

Relevant academic research and scientific papers

Spin crossover and paramagnetic behaviour in two-dimensional iron(II) coordination polymers with stilbazole push-pull ligands

The suitability of the stilbazole pushpull ligands, 4′- dimethylaminostilbazole (DMAS) and 4′-diethylaminostilbazole (DEAS), for the construction of bimetallic FeIIAgI/AuI cyanide-based coordination polymers that exhibit s

Permeant fluorescent probes visualize the activation of sarm1 and uncover an antineurodegenerative drug candidate

SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, which exhibited large red shifts after conversion. With the conjugates, SARM1 activation was visualized in live cells following elevation of endogenous NMN or treatment with a cell-permeant NMN-analog. In neurons, imaging documented mouse SARM1 activation preceded vincristine-induced axonal degeneration by hours. Library screening identified a derivative of nisoldipine (NSDP) as a covalent inhibitor of SARM1 that reacted with the cysteines, especially Cys311 in its ARM domain and blocked its NMN-activation, protecting axons from degeneration. The Cryo-EM structure showed that SARM1 was locked into an inactive conformation by the inhibitor, uncovering a potential neuroprotective mechanism of dihydropyridines.

Self-assembly of a series of thiocyanate complexes with high two-photon absorbing active in near-IR range and bioimaging applications

Abstract A series of novel complexes bearing high fluorescence quantum yields and showing the peak two-photon absorption (2 PA) cross-sections in the near-infrared region, Zn(SCN)2L2(1), [Cd(SCN)2L2]n(2), Co(SCN)2L4(3), Ni(SCN)2L4(4), [CdHgL2(SCN)4]n(5) and [MnHg(SCN)4L2]n(6), containing functional chromophore (L = (E)-(4-diethyl anilinostyryl)pyridine), were synthesized in high yields. Crystal structures of all the complexes were confirmed. Hetero-metal complexes (5, 6: L:M = 1:1) present much higher two-photon absorption (2 PA) cross-sections (σ) in comparison with those of the homo-metal complexes (L:M = 4:1 in 3 and 4, L:M = 2:1 in 1 and 2) and the free ligand (L) which may due to the fact that the hetero-metal complexes have more bridged anions (SCN-), conjugated subunits -[Hg(SCN)2M]- and -[Hg2(SCN)4M2]-. In addition, the results revealed that 2 PA response was much enhanced for the Zn(SCN)2L2 and two-photon fluorescence cell imaging experiment proved its potential application.

Synthesis, crystal structures, and solid state quadratic nonlinear optical properties of a series of stilbazolium cations combined with gold cyanide counter-ion

Three salts built up from (E)-4′-(dimethylamino)-stilbazolium (DMAS)H+, (E)-4′-(diethylamino)-stilbazolium (DEAS)H +, (E)-4′-{2-(methoxymethyl) pyrrolidinyl}-stilbazolium (MPS)H+, and gold cyanide as a counter-ion, are rep

Pyrene-excimers-based antenna systems

A series of dendrimeric compounds bearing pyrene units were synthesized to afford light-harvesting antennae based on the formation of intramolecular excimers. The synthetic plan profited from the efficiency of the Huisgen reaction, the 1,3-dipolar cycload