180975-66-0

Basic information

• Product Name: tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate
• Synonyms: tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate;1-Piperazinecarboxylic acid, 2,6-diMethyl-, 1,1-diMethylethyl ester, (2R,6S)-;(2R,6S)-tert-Butyl 2,6-diMethylpiperazine-1-carboxylate;1-Boc-(2S,6R)-2,6-diMethylpiperazine;cis-1-Boc-2,6-diMethylpiperazine;cis-2,6-Dimethyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester;(2R,6S)-rel-tert-Butyl 2,6-dimethylpiperazine-1-carboxylate;tert-butyl (2S,6R)-2,6-dimethylpiperazine-1-carboxylate
• CAS NO: 180975-66-0
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.31
• Mol File: 180975-66-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 279.7°C at 760 mmHg
• Flash Point: 123°C
• Appearance: /
• Density: 0.97g/cm³
• Vapor Pressure: 0.00394mmHg at 25°C
• Refractive Index: 1.452
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.53±0.60(Predicted)
• CAS DataBase Reference: tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate(180975-66-0)
• EPA Substance Registry System: tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate(180975-66-0)

Safety Data

• Hazardous Substances Data: 180975-66-0(Hazardous Substances Data)

Usage

General Description

Tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate is a chemical compound with the molecular formula C11H21NO2. It is a derivative of piperazine, a heterocyclic organic compound, and is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. The tert-butyl group attached to the piperazine ring provides stability and protection to the molecule, making it suitable for use in a range of chemical reactions. tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate is often used for the preparation of pharmaceuticals due to its versatile chemical properties and its ability to form important chemical bonds in drug molecules. Overall, tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate is an important intermediate in the synthesis of pharmaceutical compounds with potential therapeutic applications.

InChI:InChI=1/C11H22N2O2/c1-8-6-12-7-9(2)13(8)10(14)15-11(3,4)5/h8-9,12H,6-7H2,1-5H3/t8-,9+

Upstream product

• 623585-97-7 benzyl (3S,5R)-3,5-dimethylpiperazine-1-carboxylate 
• 21655-48-1 cis-2,6-dimethylpiperazine 
• 2080367-38-8 4-benzyl 1-(tert-butyl) (2R,6S)-2,6-dimethylpiperazine-1,4-dicarboxylate 
• 1207455-37-5 benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 108-49-6 3,5-dimethylpiperazine 

Relevant articles and documents

JAK1 SELECTIVE INHIBITORS

Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R8 have any of the meanings defined herein. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of using the same.

FUSED TRICYCLIC AMIDE COMPOUNDS AS MULTIPLE KINASE INHIBITORS

Provided are fused tricyclic amide compounds, pharmaceutical compositions comprising at least one such fused tricyclic compound, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain tricyclic amide compounds that can be useful for inhibiting multiple (specifically BRAF and/or EGFR-T790M) kinases and for treating disorders mediated thereby.

DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.