tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate
• CAS No.: 180975-66-0
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.308
• Hs Code.: 2933599090
• Mol file: 180975-66-0.mol

Synonyms:1-Piperazinecarboxylicacid, 2,6-dimethyl-, 1,1-dimethylethyl ester, cis-

Chemical Property of tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.00394mmHg at 25°C
• Refractive Index: 1.452
• Boiling Point: 279.7°C at 760 mmHg
• PKA: 8.53±0.60(Predicted)
• Flash Point: 123°C
• PSA: 41.57000
• Density: 0.97g/cm³
• LogP: 1.87040
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-1-Boc-2,6-dimethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate

There total 7 articles about tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate (1207455-37-5,2080367-38-8) → tert-butyl 2,6-dimethylpiperazine-1-carboxylate (574007-62-8,688363-66-8,180975-66-0,574007-66-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 3040.2 Torr;

Reference yield: 98.0%

→ (2R,6R)-tert-butyl 2,6-dimethylpiperazine-1-carboxylate (574007-62-8,688363-66-8,180975-66-0,574007-66-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 - 60 ℃; for 18h; Inert atmosphere;

Reference yield: 97.8%

4-benzyl 1-(tert-butyl) (2R,6S)-2,6-dimethylpiperazine-1,4-dicarboxylate (2080367-38-8) → (2R,6S)-2,6-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (574007-62-8,688363-66-8,180975-66-0,574007-66-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 17h;

upstream raw materials:

benzyl (3S,5R)-3,5-dimethylpiperazine-1-carboxylate

cis-2,6-dimethylpiperazine

4-benzyl 1-(tert-butyl) (2R,6S)-2,6-dimethylpiperazine-1,4-dicarboxylate

benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate

Refernces

• 1、 -. "1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME". . . Retrieved 2017/02/28.
• 2、 -. "METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)". Page/Page column 181. . Retrieved 2011/11/01.