18099-61-1Relevant academic research and scientific papers
A Comparative Ancillary Ligand Survey in Palladium-Catalyzed C-O Cross-Coupling of Primary and Secondary Aliphatic Alcohols
Sawatzky, Ryan S.,Hargreaves, Breanna K. V.,Stradiotto, Mark
, p. 2444 - 2449 (2016/06/01)
The utility of RockPhos, Ad-BippyPhos, JosiPhos (CyPF-tBu), and Mor-DalPhos in palladium-catalyzed C-O cross-coupling reactions involving aliphatic alcohols and (hetero)aryl halides under analogous conditions was examined, both at room temperature and at
PESTICIDAL SUBSTITUTED PHENYLETHERS
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Page/Page column 42; 63, (2008/06/13)
The invention relates to the use of phenylether derivatives of formula (I), to compositions thereof for the control of pests, including arthropods and helminths.
A novel, thioacetal based linker for solid-phase synthesis
Huwe, Christoph M.,Kuenzer, Hermann
, p. 683 - 686 (2007/10/03)
Commercially available (±)-α-lipoic acid was employed as a novel, chemically robust linker for the immobilization of ketones. The utility of this thioacetal based linker in solid-phase synthesis was demonstrated by synthesizing several 4-acetylbiphenyls and 4-alkoxyacetophenones via Suzuki and Mitsunobu reactions, respectively. The products were easily cleaved from solid support by treatment with [bis(trifluoroacetoxy)iodo]benzene.
Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors
Stewart, Andrew O.,Bhatia, Pramila A.,Martin, Jonathan G.,Summers, James B.,Rodriques, Karen E.,Martin, Michael B.,Holms, James H.,Moore, Jimmie L.,Craig, Richard A.,Kolasa, Teodozyj,Ratajczyk, James D.,Mazdiyasni, Hormoz,Kerdesky, Francis A. J.,DeNinno, Shari L.,Maki, Robert G.,Bouska, Jennifer B.,Young, Patrick R.,Lanni, Carmine,Bell, Randy L.,Carter, George W.,Brooks, Clint D. W.
, p. 1955 - 1968 (2007/10/03)
The discovery of second generation N-hydroxyurea 5-lipoxygenase inhibitors was accomplished through the development of a broad structure- activity relationship (SAR) study. This study identified requirements for improving potency and also extending duration by limiting metabolism. Potency could be maintained by the incorporation of heterocyclic templates substituted with selected lipophilic substituents. Duration of inhibition after oral administration was optimized by identification of structural features in the proximity of the N-hydroxyurea which correlated to low in vitro glucuronidation rates. Furthermore, the rate of in vitro glucuronidation was shown to be stereoselective for certain analogs. (R)-N- [3-[5-(4-Fluorophenoxy)-2-furyl]-1-methyl-2-propynyl]-N-hydroxyurea (17c) was identified and selected for clinical development.
Arylglyoxals
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, (2008/06/13)
Arylglyoxals which are new compounds active as hypoglycemic agents.
