181026-04-0Relevant articles and documents
Chemical approaches to bacterial vaccines. Synthesis of mycobacterial oligosaccharide-protein conjugates for use as serodiagnostics and immunogens
Dubois, Eric P.,Robbins, John B.,Pozsgay, Vince
, p. 1387 - 1392 (1996)
Di- to penta-saccharide fragments (2-5) of Polysaccharide II (PS-II) of Mycobacterium tuberculosis were synthesized in spacer-linked form in a stepwise fashion using a new glycosyl donor featuring a trans-fused isopropylidene diol-protecting group. Covalent attachment of the oligosaccharides to proteins provides semi-synthetic antigens and immunogens which are being used to probe the role of PS-II as a possible mycobacterial antigen.