181038-07-3

Upstream product

• 119-61-9 benzophenone 
• 74307-97-4 2-chloromethyl-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 1772-43-6 2,4,4-trimethyl oxazoline 

Downstream Products

• 181038-11-9 1-(4,4-dimethyl-2-oxazolin-2-yl)-1,2-epoxy-2,2-diphenylethane 

Relevant academic research and scientific papers

An oxazoline-mediated synthesis of formyl epoxides

α,β-epoxy aldehydes have been prepeared by deblocking of oxazolinyl oxiranes, which in turn have been synthesized on treatment of 4,4-dimethyloxazolinylchlormethyllithium with aldehydes.

Metalation of 2-chloromethyl-2-oxazolines: Synthesis of 1,2,3-tris(oxazolinyl)cyclopropanes and derivatives

2-Chloromethyl-2-oxazoline converts cleanly into trans-1,2,3-tris(oxazolinyl)cyclopropane upon treatment with strong bases such as LDA or KN(SiMe3)2. Deprotonation of the above cyclopropane followed by the addition of electrophiles allows the preparation of more functionalized tris-(oxazolinyl)cyclopropanes.