74307-97-4

Upstream product

• 1772-43-6 2,4,4-trimethyl oxazoline 
• 36743-66-5 ethyl chloroacetimidate hydrochloride 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 86354-11-2 (4,4-dimethyl-4,5-dihydrooxazolyl-2-yl)methanol 

Downstream Products

• 144397-12-6 Benzyl-(4,4-dimethyl-4,5-dihydro-oxazol-2-ylmethyl)-carbamic acid benzyl ester 
• 116233-37-5 2-[(E)-1-((1R,2S)-3-Benzyloxy-1-methoxymethoxy-2-methyl-propyl)-1-methyl-but-2-enyloxymethyl]-4,4-dimethyl-4,5-dihydro-oxazole 
• 133649-39-5 2-[(E)-(R)-1-((R)-1-Benzyloxymethoxy-propyl)-1-methyl-but-2-enyloxymethyl]-4,4-dimethyl-4,5-dihydro-oxazole 
• 116233-37-5 2-[(E)-(S)-1-((1R,2S)-3-Benzyloxy-1-methoxymethoxy-2-methyl-propyl)-1-methyl-but-2-enyloxymethyl]-4,4-dimethyl-4,5-dihydro-oxazole 
• 148338-52-7 2-{(E)-(R)-1-[(2S,3S,6S)-6-((R)-2-Benzyloxy-1-methyl-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-1-methyl-but-2-enyloxymethyl}-4,4-dimethyl-4,5-dihydro-oxazole 
• 161236-68-6 4,4-Dimethyl-2-(4-methyl-benzyloxymethyl)-4,5-dihydro-oxazole 
• 161236-69-7 2-(4-Chloro-benzyloxymethyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 161236-67-5 2-(4-Methoxy-benzyloxymethyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 161236-66-4 2-Benzyloxymethyl-4,4-dimethyl-4,5-dihydro-oxazole 
• 181038-07-3 2-Chloro-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-1,1-diphenyl-ethanol 

Relevant academic research and scientific papers

Synthesis and catalytic activity of spaced ferrocene oxazolines

Chiral 2-[{N-aryl-N-(ferrocenylmethyl)amino}methyl]-4-(1-methylethyl)-4, 5-dihydroxazoles with various substituents at the aryl ring were prepared by alkylation of N-(ferrocenyl-methyl)anilines, FcCH2NHC 6H4R (Fc = ferrocenyl), with (S)-2-(chloromethyl)-4-(1-methylethyl)-4,5-dihydrooxazole. The oxazoles, substituted anilines, and the precursors of the latter, the respective Schiff bases FcCH=NC6H4R, were characterized by standard methods and further studied by mass spectrometry. The oxazoles were further tested as chiral auxiliaries in the addition of diethylzinc to benzaldehyde but showed only negligible asymmetric induction (ee ca 10%), most likely due to steric hindrance of the nitrogen donor centres. This steric restriction seems to be lowered upon replacement of the substituted phenyl group with a benzyl substituent; compounds FcCH2NHCH2Ph and (R)-FcCH 2NHCH(Me)Ph are easily alkylated yielding [FcCH2NMe 2(CH2Ph)]I (9) and 2-[{N-(1-phenylethyl)-N-(ferrocenylmethyl)amino}methyl]-4-(1-methylethyl)-4, 5-dihydroxazole (10), respectively. Solid-state structures of FcCH 2NHC6H4R (R = 2-Me and 4-Cl), 9, and 10 have been determined by single-crystal X-ray diffraction.

BETA CARBOLINES AND USES THEREOF

This invention provides beta-carboline compounds of formula I: wherein R1, R2, R3, R4, R5, G, and x are as described in the specification. The compounds are useful for treating cancer and inflammatory disorders.

An oxazoline-mediated synthesis of formyl epoxides

α,β-epoxy aldehydes have been prepeared by deblocking of oxazolinyl oxiranes, which in turn have been synthesized on treatment of 4,4-dimethyloxazolinylchlormethyllithium with aldehydes.

Preparation of functionalized oxazolines

The preparation of several oxazolines substituted at C-2 by an hetero substituted methyl group is reported. 2-Aminomethyl, 2-azidomethyl, 2-nitromethyl and 2-hydroxymethyl oxazolines were obtained by substitution of the corresponding 2-halogenomethyl oxazolines. On the other hand, 2-benzyloxycarbonylaminomethyl, 2-thiophenylmethyl, 2-selenophenylmethyl oxazolines were prepared by condensation of the appropriate iminoether with a β-aminoalcohol.