181040-28-8

Basic information

• Product Name: methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(pyridazin-4-ylmethoxy)phenoxy]acetate
• Synonyms: methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(pyridazin-4-ylmethoxy)phenoxy]acetate
• CAS NO: 181040-28-8
• Molecular Weight: 409.829
• Mol File: 181040-28-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(pyridazin-4-ylmethoxy)phenoxy]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(pyridazin-4-ylmethoxy)phenoxy]acetate(181040-28-8)
• EPA Substance Registry System: methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(pyridazin-4-ylmethoxy)phenoxy]acetate(181040-28-8)

Safety Data

• Hazardous Substances Data: 181040-28-8(Hazardous Substances Data)

Upstream product

• 50901-48-9 4-chloromethylpyridazine hydrochloride 
• 181039-78-1 methyl (RS)-(2-chlorophenyl)-[2-cyano-5-hydroxyphenoxy]acetate 
• 181039-77-0 methyl (RS)-(5-allyloxy-2-cyanophenoxy)-(2-chlorophenyl)acetate 
• 181039-75-8 2-Acetoxy-4-allyloxybenzonitrile 
• 181039-76-9 4-allyloxy-2-hydroxybenzonitrile 
• 85259-19-4 methyl 2-bromo-2-(2-chlorophenyl)acetate 
• 89-98-5 2-chloro-benzaldehyde 
• 156276-21-0 rac-methyl 2-chloromandelate 
• 10421-85-9 2-chloromandelic acid 
• 94693-72-8 4-(chloromethyl)pyridazine 

Relevant articles and documents

SUBSTITUTED PHENYL COMPOUNDS WITH A SUBSTITUENT HAVING A 1,3-BENZODIOXOLE RING

This invention is directed to compounds of formula I STR1 wherein R 1 is CN, CH 2 CN, CH=CHCN, CHO, or CH=CHCO. sub. 2 H;R 2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R 3 is halogen;R 4 is optionally substituted aryl or optionally substituted heteroaryl;R. sup.5 is carboxy or an acid isostere; X is oxygen or sulphur; and n is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.