156276-21-0Relevant articles and documents
Bioreduction of methyl o-chlorobenzoylformate at 500 g L-1 without external cofactors for efficient production of enantiopure clopidogrel intermediate
Ni, Yan,Pan, Jiang,Ma, Hong-Min,Li, Chun-Xiu,Zhang, Jie,Zheng, Gao-Wei,Xu, Jian-He
, p. 4715 - 4717 (2012)
Biocatalytic reduction of methyl o-chlorobenzoylformate (CBFM) provides a green and direct access to methyl (R)-o-chloromandelate [(R)-CMM], an intermediate for a platelet aggregation inhibitor named clopidogrel. As much as 500 g L-1 of CBFM wa
Generation of Tosyl Azide in Continuous Flow Using an Azide Resin, and Telescoping with Diazo Transfer and Rhodium Acetate-Catalyzed O–H Insertion
Collins, Stuart G.,Lynch, Denis,Maguire, Anita R.,O'callaghan, Katie S.,O'mahony, Rosella M.
, p. 2772 - 2785 (2021/12/13)
Generation of tosyl azide 12 in acetonitrile in flow under water-free conditions using an azide resin and its use in diazo transfer to a series of aryl acetates are described. Successful telescoping with a rhodium acetate-catalyzed O–H insertion has been
Boron-Catalyzed O-H Bond Insertion of α-Aryl α-Diazoesters in Water
San, Htet Htet,Wang, Shi-Jun,Jiang, Min,Tang, Xiang-Ying
supporting information, p. 4672 - 4676 (2018/08/09)
A catalytic, metal-free O-H bond insertion of α-diazoesters in water in the presence of B(C6F5)3·nH2O (2 mol %) was developed, affording a series of α-hydroxyesters in good to excellent yields. The reaction features easy operation and wide substrate scope, and importantly, no metal is needed as compared with the conventional methods. Significantly, this approach further expands the applications of B(C6F5)3 under water-tolerant conditions.
