181075-66-1

Basic information

• Product Name: methyl (3S)-3-amino-5-methylhexanoate
• Synonyms: methyl (3S)-3-amino-5-methylhexanoate
• CAS NO: 181075-66-1
• Molecular Weight: 159.228
• Mol File: 181075-66-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl (3S)-3-amino-5-methylhexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (3S)-3-amino-5-methylhexanoate(181075-66-1)
• EPA Substance Registry System: methyl (3S)-3-amino-5-methylhexanoate(181075-66-1)

Safety Data

• Hazardous Substances Data: 181075-66-1(Hazardous Substances Data)

Upstream product

• 279256-99-4 (S)-5-methyl-3-(o-nitrobenzenesulfonamido)hexanoic acid methyl ester 
• 67-56-1 methanol 
• 138165-75-0 N-Boc-L-β-homoleucine 
• 109687-65-2 (S)-(-)-1,1-dimethylethyl <3-methyl-1-<<(methylsulfonyl)oxy>methyl>butyl>carbamate 
• 82010-31-9 (S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester 
• 66866-44-2 Boc-Leu-O-COO-isoBu 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 172695-24-8 (S)-3-<(tert-butoxycarbonyl)amino>-5-methylhexanenitrile 
• 180037-68-7 (R)-4-(2-methylpropyl)-oxetane-2-one 

Downstream Products

• 1190881-05-0 C₂₂H₃₅N₃O₅ 
• 1228754-17-3 Z-β-Cys(BzI)-ψ[NH-CS-NH]-β-Leu-OMe 
• 1036275-17-8 N-[(S)-1-methoxycarbonyl-4-methylpentyl]-(+/-)-2-cyano-2-fluoro-p-tolylacetamide 
• 181075-77-4 (S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester 
• 181075-76-3 (S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester 

Relevant articles and documents

A multifaceted secondary structure mimic based on piperidine-piperidinones

Minimalist secondary structure mimics are typically made to resemble one interface in a protein-protein interaction (PPI), and thus perturb it. We recently proposed suitable chemotypes can be matched with interface regions directly, without regard for secondary structures. Here we describe a modular synthesis of a new chemotype 1, simulation of its solution-state conformational ensemble, and correlation of that with ideal secondary structures and real interface regions in PPIs. Scaffold 1 presents amino acid side-chains that are quite separated from each other, in orientations that closely resemble ideal sheet or helical structures, similar non-ideal structures at PPI interfaces, and regions of other PPI interfaces where the mimic conformation does not resemble any secondary structure. 68 different PPIs where conformations of 1 matched well were identified. A new method is also presented to determine the relevance of a minimalist mimic crystal structure to its solution conformations. Thus dld-1-faf crystallized in a conformation that is estimated to be 0.91 kcal-mol-1 above the minimum energy solution state. Do we know, when designing a new peptidomimetic scaffold like the one shown, how it can resemble secondary structures? Design and modular synthesis of this elongated mimic is reported, and the structure is related to ideal and real structures at PPI interfaces.

Divergent reaction pathways in amine additions to β-lactone electrophiles. An application to β-peptide synthesis

β-Lactone electrophiles are subject to regioselective addition-elimination (AE) or SN2 ring opening with various nitrogen-based nucleophiles. Primary and secondary amines promote AE ring opening to deliver products that are the functional equiv