18110-43-5

Upstream product

• 94626-26-3 Phosphoric acid 2-phenylethyl dimethyl ester 
• 60-12-8 2-phenylethanol 
• 31735-82-7 Phenaethylphosphorodichloridat 
• 162554-47-4 bis<2-(methyldiphenylsilyl)ethyl> phenethyl phosphate 
• 1026544-75-1 Phosphorous acid bis-[2-(methyl-diphenyl-silanyl)-ethyl] ester phenethyl ester 

Relevant academic research and scientific papers

Isolation and production of catalytic antibodies using phage technology

Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies, from bacteriophage. The methods require the cloning, selection, screening, and isolation of catalytic antibodies. Also disclosed and claimed are the products themselves, the catalytic antibodies, made from the phage technology. In addition, catalytic antibodies produced from the phage technology and useful in prodrug activation are disclosed and claimed. And finally, the invention also understands the production of catalytic antibodies to phosphonates.

A Mild Preparation of Protected Phosphate Esters from Alcohols

Treatment of a wide variety of alcohols with trimethyl phosphite and carbon tetrabromide in pyridine leads to the formation of the corresponding dimethyl phosphate esters in high yields.The reaction is presumed to proceed by formation of an intermediate a

Use of Bis N,N-Dialkylphosphoramidites for the Synthesis of Phosphate Monoesters

The bis N,N-dialkylphosphoramidites 7a and b and bis N,N-dialkylphosphoramidites 6a and b have been prepared by reaction of the N,N-dialkylphosphorochloridites 5a and b with the appropriate 2-(trialkylsilyl)ethanol.In the presence of 1H-tetrazole, the phosphoramidites 6a, b and 7a, b phosphorylated MeOH, PhCH2OH, PhCH2CH2OH, Me(PhCH2CH2(CHOH, 2,3,4,5,6-penta-O-benzyl-myo-inositol and ButOH, to give the phosphites 8a-h.Without isolation, these were oxidized to the corresponding phosphate triesters 9a-h with m-chloroperbenzoic acid.Treatment of the triesters 9a-h with tetrabutylammonium fluoride removes only 2-(trialkylsilyl)ethyl group to give the diesters 10a-h, whereas treatment with a solution of hydrofluoric acid in acetonitrile-water gives the phosphate monoesters 11a-e.