181119-01-7Relevant academic research and scientific papers
Enantioselective synthesis of isoxazolidinyl thymine and cytosine nucleosides
Xiang, Yuejun,Gong, Youxiang,Zhao, Kang
, p. 4877 - 4880 (1996)
A diastereo- and enantioselective synthesis of isoxazolidinyl nucleosides (4) is described. The required isoxazolidine intermediate (16) was successfully prepared by the dioxolane-derived tautomerization of the corresponding lactol (13) which, in turn, was obtained from the reduction of the Michael adduct of N-methyl hydroxylamine and the unsaturated γ-lactone (5).
