Enantioselective synthesis of isoxazolidinyl thymine and cytosine nucleosides

DOI: 10.1016/0040-4039(96)00999-9

Source and publish data:

Tetrahedron Letters p. 4877 - 4880 (1996)

Update date:2022-08-03

Topics:

Authors:

Xiang, Yuejun

Gong, Youxiang

Zhao, Kang

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Article abstract of DOI:10.1016/0040-4039(96)00999-9

A diastereo- and enantioselective synthesis of isoxazolidinyl nucleosides (4) is described. The required isoxazolidine intermediate (16) was successfully prepared by the dioxolane-derived tautomerization of the corresponding lactol (13) which, in turn, was obtained from the reduction of the Michael adduct of N-methyl hydroxylamine and the unsaturated γ-lactone (5).

Full text of DOI:10.1016/0040-4039(96)00999-9

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