181125-98-4Relevant academic research and scientific papers
Dual evaluation of some novel 2-amino-substituted coumarinylthiazoles as anti-inflammatory-antimicrobial agents and their docking studies with COX-1/COX-2 active sites
Chandak, Navneet,Kumar, Pawan,Kaushik, Pawan,Varshney, Parul,Sharma, Chetan,Kaushik, Dhirender,Jain, Sudha,Aneja, Kamal R.,Sharma, Pawan K.
, p. 476 - 484 (2014/08/05)
Synthesis of total eighteen 2-amino-substituted 4-coumarinylthiazoles including sixteen new compounds (3a-o and 5b) bearing the benzenesulfonamide moiety is described in the present report. All the synthesized target compounds were examined for their in vivo anti-inflammatory (AI) activity and in vitro antimicrobial activity. Results revealed that six compounds (3d, 3f, 3g, 3h, 3j and 3n) exhibited pronounced anti-inflammatory activity comparable to the standard drug indomethacin. AI results were further confirmed by the docking studies of the most active (3n) and the least active compound (3a) with COX-1 and COX-2 active sites. In addition, most of the compounds exhibited moderate antimicrobial activity against Gram-positive bacteria as well as fungal yeast, S. cervisiae. Comparison between 3 and 5 indicated that incorporation of additional substituted pyrazole nucleus into the scaffold significantly enhanced AI activity.
Synthesis of Some New Types of Thiazolyl Coumarins
Rao, V. Rajeswar,Rao, G. Mohan,Kumar, V. Ravi,Vardhan, V. Aditya
, p. 47 - 52 (2007/10/03)
3-Acetyl coumarins I react with substituted sulfanilamides in the presence of iodine to give substituted 3-(2-arylamino-4-thiazolyl)-2H-1-benzopyran-2-ones (II). The structures of these compounds have been confirmed and they were converted into their acet
