1718-39-4

Basic information

• Product Name: 4-THIOUREIDO-BENZENESULFONAMIDE
• Synonyms: AKOS BBS-00002150;4-[(AMINOCARBONOTHIOYL)AMINO]BENZENESULFONAMIDE;4-THIOUREIDO-BENZENESULFONAMIDE;ART-CHEM-BB B023270;1-(4-sulfaMoylphenyl)-1-sulfanylurea
• CAS NO: 1718-39-4
• Molecular Formula: C₇H₉N₃O₂S₂
• Molecular Weight: 231.3
• Mol File: 1718-39-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 209 °C
• Boiling Point: 448 °C at 760 mmHg
• Flash Point: 224.8 °C
• Appearance: /
• Density: 1.578 g/cm³
• Storage Temp.: 2-8°C
• PKA: 9.99±0.12(Predicted)
• CAS DataBase Reference: 4-THIOUREIDO-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-THIOUREIDO-BENZENESULFONAMIDE(1718-39-4)
• EPA Substance Registry System: 4-THIOUREIDO-BENZENESULFONAMIDE(1718-39-4)

Safety Data

• Hazardous Substances Data: 1718-39-4(Hazardous Substances Data)

Usage

General Description

4-THIOUREIDO-BENZENESULFONAMIDE, also known as tosic acid, is a chemical compound with the molecular formula C7H9N3O2S2. It is a derivative of benzenesulfonamide and is commonly used as a reagent in organic synthesis and as a pharmaceutical intermediate. 4-THIOUREIDO-BENZENESULFONAMIDE is a white to off-white crystalline powder that is insoluble in water but soluble in most organic solvents. It is widely used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. It is also used as a reagent for the conversion of amines to thioureas, and as a source of cyanate in the controlled release of isocyanates.

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 6101-31-1 sulfanilamide hydrochloride 
• 7647-01-0 hydrogenchloride 
• 63-74-1 sulfanilamide 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 81059-98-5 2-(4-sulphonamidophenyl)-amino-Δ²-thiazolin-4-one 
• 66121-85-5 4-[4-(4-bromo-phenyl)-thiazol-2-ylamino]-benzenesulfonamide 
• 66121-82-2 4-(4-phenylthiazol-2-ylamino)benzenesulfonamide 
• 66121-86-6 4-[4-(4-iodo-phenyl)-thiazol-2-ylamino]-benzenesulfonamide 
• 66121-83-3 4-(4-p-tolylthiazol-2-ylamino)benzenesulfonamide 
• 66121-88-8 4-[4-(2,5-dichloro-phenyl)-thiazol-2-ylamino]-benzenesulfonamide 
• 79065-26-2 3H-2-imino-3-(p-sulfamylphenyl)-5,7-dimethylpyrido-<3,4-e>-1,3-thiazin-4-one 
• 181125-98-4 4-[[4-(2-oxo-2H-1-benzopyran-3-yl)-2-thiazolyl]amino]benzene sulphonamide 
• 181125-99-5 4-[4-(6-bromo-2-oxo-2H-chromen-3-yl)-thiazol-2-ylamino]-benzenesulfonamide 
• 181126-00-1 4-[4-(6,8-dibromo-2-oxo-2H-chromen-3-yl)-thiazol-2-ylamino]-benzenesulfonamide 

Relevant articles and documents

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides

A series of benzo[d]thiazole-5- and 6-sulfonamides has been synthesized and investigated for the inhibition of several human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoforms, using ethoxzolamide (EZA) as lead molecule. 2-Amino-substituted, 2-acylamino- an

Design, synthesis, and antipoliferative activities of novel substituted imidazole-thione linked benzotriazole derivatives

A new series of benzotriazole moiety bearing substituted imidazol-2-thiones at N1 has been designed, synthesized and evaluated for in vitro anticancer activity against the different cancer cell lines MCF-7(breast cancer), HL-60 (Human promyelocytic leukemia), and HCT-116 (colon cancer). Most of the benzotriazole analogues exhibited promising antiproliferative activity against tested cancer cell lines. Among all the synthesized compounds, BI9 showed potent activity against the cancer cell lines such as MCF-7, HL-60 and HCT-116 with IC50 3.57, 0.40 and 2.63 μM, respectively. Compound BI9 was taken up for elaborate biological studies and the HL-60 cells in the cell cycle were arrested in G2/M phase. Compound BI9 showed remarkable inhibition of tubulin polymerization with the colchicine binding site of tubulin. In addition, compound BI9 promoted apoptosis by regulating the expression of pro-apoptotic protein BAX and anti-apoptotic proteins Bcl-2. These results provide guidance for further rational development of potent tubulin polymerization inhibitors for the treatment of cancer.

Inhibitors of apoptosis in testicular germ cells: Synthesis and biological evaluation of some novel IBTs bearing sulfonamide moiety

Pifithrin-α, a known p53 inactivator, inhibits p53-dependant mitochondrial cell death induced by toxins or γ-radiation. It has been found that aromatic IBT analogues of PFT-α are more cytoprotective and nonpeptide-based, isatin sulfonamides selectively in