18113-04-7

Basic information

• Product Name: 2-Chloro-5-methoxyphenol
• Synonyms: 2-CHLORO-5-METHOXYPHENOL;2-Chloro-5-methoxyphenol 98%;6-Chlororesorcinol monomethyl ether (OH=1);Phenol, 2-chloro-5-methoxy-
• CAS NO: 18113-04-7
• Molecular Formula: C₇H₇ClO₂
• Molecular Weight: 158.58
• Product Categories: blocks;BuildingBlocks
• Mol File: 18113-04-7.mol

Chemical Properties

• Boiling Point: 100-105/15mm
• Flash Point: 101.416 °C
• Appearance: Yellow liquid
• Density: 1.281 g/cm³
• Vapor Pressure: 0.0198mmHg at 25°C
• Refractive Index: gt. 1.5620-1.5660
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.12±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-5-methoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-methoxyphenol(18113-04-7)
• EPA Substance Registry System: 2-Chloro-5-methoxyphenol(18113-04-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 18113-04-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow liquid

InChI:InChI=1/C7H7ClO2/c1-10-5-2-3-6(8)7(9)4-5/h2-4,9H,1H3

Upstream product

• 150-19-6 O-methylresorcine 
• 2401-24-3 2-chloro-5-methoxyaniline 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 16807-60-6 3-methoxycyclohex-2-en-1-one 

Downstream Products

• 38946-61-1 2-chloro-4-(1,1-dimethylethyl)-5-methoxyphenol 
• 26378-25-6 2-(2-Bromo-ethoxy)-1-chloro-4-methoxy-benzene 
• 1034890-85-1 3-chloro-5-(2-chloro-5-methoxyphenoxy)benzonitrile 
• 920036-12-0 3-chloro-5-(2-chloro-5-hydroxyphenoxy)benzonitrile 
• 1616855-08-3 3-(2-chloro-5-methoxyphenoxy)-4-methylpentan-1-ol 
• 1616852-22-2 2-(3-methoxy-1-(1-(3-(3-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-2-oxoindolin-3-yl)-N-methylacetamide 
• 1616852-20-0 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methoxy-2-oxoindolin-3-yl)-N-methylacetamide 
• 1616852-02-8 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-hydroxy-2-oxoindolin-3-yl)acetamide 
• 1616854-32-0 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-2-oxoindolin-3-yl)acetamide 
• 1616852-00-6 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-hydroxy-2-oxoindolin-3-yl)-N,N-dimethylacetamide 
• 1616854-30-8 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-2-oxoindolin-3-yl)-N,N-dimethylacetamide 
• 1616851-91-2 2-(1-(1-(3-(3-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide 
• 1616851-89-8 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide 
• 1616851-87-6 C₂₉H₃₈ClN₃O₅ 

Relevant articles and documents

NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES

The invention relates to novel compounds of the formula (I) in which Z, Y, A1, A2, A3, A4, X, R7, R8 and R9 have the meanings mentioned above, and processes and intermediates for the preparation thereof, and their use for controlling animal pests, in particular insects.

DIARYLETHER-BASED FLUOROGENIC PROBES FOR DETECTION OF HYPOCHLOROUS ACID OR HYDROXYL RADICAL

Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening hypochlorous acid or hydroxyl radical. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining hypochlorous acid or hydroxyl radical in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of hypochlorous acid or hydroxyl radical in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening hypochlorous acid or hydroxyl radical or compounds that can increase or decrease the level of hypochlorous acid or hydroxyl radical in chemical and biological samples.

Practical regioselective halogenation of vinylogous esters: Synthesis of differentiated mono-haloresorcinols and polyhalogenated resorcinols

A practical and efficient method for the direct, regioselective conversion of vinylogous esters to haloresorcinols is reported. Control of the reaction conditions enables synthesis of either the 4- or 6-haloresorcinol isomers from a common precursor with excellent regiocontrol and high yield. The generality and functional group tolerance of this novel protocol is demonstrated. The utility of this methodology to access polyhaloresorcinols is also reported. These methods create useful functionalized building blocks for further synthetic applications.

Regiodivergent halogenation of vinylogous esters: One-pot, transition-metal-free access to differentiated haloresorcinols

We report an efficient method for the regiodivergent synthesis of halogenated resorcinol derivatives using readily available vinylogous esters and sulfonyl halide halogen donors. Either the 4- or 6-haloresorcinol isomer is accessible from a common precursor. In contrast to conventional oxidants for arene halogenation, mild sulfonyl halides allow broad functional group compatibility. The strategy inherently differentiates the two resorcinol oxygen atoms and enhances the potential for complex molecule synthesis.

Pharmaceutically Active Pyrazine Derivatives

The invention provides compounds which inhibit or modulate the activity of Chk-1 kinase and which are useful in the treatment of cancer. The compounds have the general formula (1): and salts, N-oxides and tautomers thereof, wherein m is 2, 3 or 4; n is 0

HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

PHARMACEUTICALLY ACTIVE PYRAZINE DERIVATIVES

The invention provides compounds which inhibit or modulate the activity of Chk-1 kinase and which are useful in the treatment of cancer. The compounds have the general formula (1) and salts, N-oxides and tautomers thereof, wherein m is 2, 3 or 4; n is 0 o