181132-99-0

Basic information

• Product Name: N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-pyridinyl)[1,1'-biphenyl]-2-sulfonamide
• CAS NO: 181132-99-0
• Molecular Weight: 405.477
• Mol File: 181132-99-0.mol

Chemical Properties

• CAS DataBase Reference: N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-pyridinyl)[1,1'-biphenyl]-2-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-pyridinyl)[1,1'-biphenyl]-2-sulfonamide(181132-99-0)
• EPA Substance Registry System: N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-pyridinyl)[1,1'-biphenyl]-2-sulfonamide(181132-99-0)

Safety Data

• Hazardous Substances Data: 181132-99-0(Hazardous Substances Data)

Upstream product

• 181133-18-6 N-(3,4-Dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-pyridinyl)[1,1'-biphenyl]-2-sulfonamide 
• 63996-36-1 2-(4-bromophenyl]pyridine 
• 176961-13-0 2-borono-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-benzenesulfonamide 

Relevant articles and documents

Biphenylsulfonamide endothelin receptor antagonists. Part 3: Structure-activity relationship of 4′-heterocyclic biphenylsulfonamides

A number of 4′-heterocyclic biphenylsulfonamide derivatives, formally derived from BMS-193884 (1) by replacing the oxazole ring with other heterocyclic rings, are potent and selective endothelin A (ETA) receptor antagonists. Among the analogues examined, the pyrimidine derivative 18 is the most potent (Ki=0.9 nM) and selective for the ETA receptor, approximately equivalent to 1.

SUBSTITUTED BIPHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS

Compounds of the formula STR1 in which the symbols are as defined herein, inhibit the activity of endothelin.

SUBSTITUTED BIPHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS

Compounds of the formula STR1 inhibit the activity of endothelin.