181136-33-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-4-methoxybenzohydrazide is used as a pharmaceutical precursor for the synthesis of various organic compounds, contributing to the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
As a chemical compound, 3-Bromo-4-methoxybenzohydrazide is used as a precursor in the synthesis of other organic compounds, facilitating the creation of a range of chemical products.
Used in Antimicrobial Applications:
3-Bromo-4-methoxybenzohydrazide is used as an antimicrobial agent due to its ability to inhibit the growth of certain microorganisms, making it potentially useful in the development of new antimicrobial treatments.
Used in Antitumor Applications:
3-Bromo-4-methoxybenzohydrazide is used as an antitumor agent, showing potential in the inhibition of tumor growth, which could lead to its incorporation in cancer treatment strategies.
Used in Research:
In the field of research, 3-Bromo-4-methoxybenzohydrazide is used as a subject of study for its reducing properties in chemical reactions, providing insights into its potential applications and mechanisms of action.

InChI:InChI=1/C8H9BrN2O2/c1-13-7-3-2-5(4-6(7)9)8(12)11-10/h2-4H,10H2,1H3,(H,11,12)

Upstream product

• 460079-82-7 ethyl 3-bromo-4-methoxybenzoate 
• 99-58-1 3-bromo-4-methoxybenzoic acid 
• 35450-37-4 methyl 3-bromo-4-methoxybenzoate 

Downstream Products

• 181136-47-0 4-Amino-5-(3-bromo-4-methoxy-phenyl)-4H-[1,2,4]triazole-3-thiol 

Relevant academic research and scientific papers

Structure-Activity Relationship of Phenylpyrazolones against Trypanosoma cruzi

Chagas disease is a neglected parasitic disease caused by the parasitic protozoan Trypanosoma cruzi and currently affects around 8 million people. Previously, 2-isopropyl-5-(4-methoxy-3-(pyridin-3-yl)phenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (NPD-0227) was discovered to be a sub-micromolar inhibitor (pIC50=6.4) of T. cruzi. So far, SAR investigations of this scaffold have focused on the alkoxy substituent, the pyrazolone nitrogen substituent and the aromatic substituent of the core phenylpyrazolone. In this study, modifications of the phenyldihydropyrazolone scaffold are described. Variations were introduced by installing different substituents on the phenyl core, modifying the geminal dimethyl and installing various bio-isosteres of the dihydropyrazolone group. The anti T. cruzi activity of NPD-0227 could not be surpassed as the most potent compounds show pIC50 values of around 6.3. However, valuable additional SAR data for this interesting scaffold was obtained, and the data suggest that a scaffold hop is feasible as the pyrazolone moiety can be replaced by a oxazole or oxadiazole with minimal loss of activity.

Synthesis, characterisation and antifungal activity of some N-bridged heterocycles derived from 3-(3-bromo-4-methoxyphenyl)-4-amino-5-mercapto-1,2,4-triazole

3-(3-Bromo-4-methoxyphenyl)-4-amino-5-mercapto-1,2,4-triazole was prepared starting from p-anisic acid. This new triazole was employed in the synthesis of some N-bridged heterocycles. All the newly synthesized compounds were characterized by analytical, IR, 1H-NMR and Mass Spectral studies. Some of the newly synthesized compounds were screened for their antifungal property against Thielaviopsis paradoxa, a fungus which is reported to cause stem-bleeding disease in coconut plants.