181207-67-0Relevant academic research and scientific papers
Substrate-Based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase
Baguley, Tyler D.,Xu, Hai-Chao,Chatterjee, Manavi,Nairn, Angus C.,Lombroso, Paul J.,Ellman, Jonathan A.
, p. 7636 - 7650 (2013/11/06)
High levels of striatal-enriched protein tyrosine phosphatase (STEP) activity are observed in a number of neuropsychiatric disorders such as Alzheimer's disease. Overexpression of STEP results in the dephosphorylation and inactivation of many key neuronal
Amino-imidazolones for the inhibition of beta-secretase
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Page/Page column 10, (2008/06/13)
The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
