181218-62-2

Upstream product

• 117998-35-3 1-(2-deoxy-β-D-erythro-pentofuranosyl)-4-<(2-aminoethyl)-amino>-5-methylpyrimidin-2(1H)-one 
• 162049-17-4 6-(p-bromobenzoylamino)caproic acid N-hydroxysuccinimide ester 
• 50-89-5 thymidine 
• 80991-41-9 1-(3,5-Di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone 
• 6979-97-1 3',5'-diacetylthymidine 

Relevant academic research and scientific papers

Synthesis of 5-methyl-2'-O-deoxycytidine analogs to determine monoclonal antibody specificity in the recognition of the 6-(p-bromobenzoylamino) caproyl radical

Eight new p-bromobenzoyl derivatives of 5-methyl-2'-O-deoxycytidine analogs, substituted at the 4-position, were synthesized. The best conditions for obtaining 5-methyl-4-N-aminoalkyl-2'-O-deoxycytidine from 3',5'-di-O- acetyl-4-(1,2,4-triazol-1-yl)-2'-O-deoxythymidine were studied. The nucleoside analogs were used to identify the fragment of the 6-(p- bromobenzoylamino)caproyl radical that binds to the monoclonal antibody obtained against it and to define an affinity scale of monoclonal antibody against them.