117998-35-3

Upstream product

• 80991-41-9 1-(3,5-Di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone 
• 107-15-3 ethylenediamine 
• 50-89-5 thymidine 
• 6979-97-1 3',5'-diacetylthymidine 
• 91290-54-9 1-(2-Deoxy-3,5-di-O-acetyl-β-D-ribofuranosyl)-4-chloro-5-methyl-2(1H)-pyrimidinone 

Downstream Products

• 181218-62-2 5-methyl-4-N-{2-[ε-(p-bromobenzoylamino)caproylamino]ethyl}-2'-O-deoxycytidine 

Relevant academic research and scientific papers

New derivatives of pyrimidine nucleosides: Synthesis, physico-chemical properties and biological activity

The paper reports the synthesis and physico-chemical data of eight new pyrimidine nucleosides C-4 substituted and two imidazol[1,2-c]pyrimidine nucleosides as well as preliminary results of their biological effects on neuroblastoma cells in culture.

Synthesis of 5-methyl-2'-O-deoxycytidine analogs to determine monoclonal antibody specificity in the recognition of the 6-(p-bromobenzoylamino) caproyl radical

Eight new p-bromobenzoyl derivatives of 5-methyl-2'-O-deoxycytidine analogs, substituted at the 4-position, were synthesized. The best conditions for obtaining 5-methyl-4-N-aminoalkyl-2'-O-deoxycytidine from 3',5'-di-O- acetyl-4-(1,2,4-triazol-1-yl)-2'-O-deoxythymidine were studied. The nucleoside analogs were used to identify the fragment of the 6-(p- bromobenzoylamino)caproyl radical that binds to the monoclonal antibody obtained against it and to define an affinity scale of monoclonal antibody against them.