181228-86-4

Upstream product

• 135297-04-0 (3S,4R)-4-[(1R,2S,3R)-2,3-epoxycyclohexyl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one 

Downstream Products

• 135297-26-6 ((1S,3R)-3-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-cyclohexyl)-carbamic acid allyl ester 
• 135297-25-5 (3S,4R)-4-((1R,3S)-3-Azido-2-oxo-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of 4-amino trinems

This article deals with the study carried out on the synthesis of 4-amino substituted trinems 1 starting from the key-intermediate (3S, 4R)-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-4-[(1'R, 2'S, 3'R)-1',2'-epoxycyclohex-3'-yl]azetidin-2-one 2. In particular, epoxide opening with various amines and subsequent cyclization to the corresponding trinems were explored. Their synthesis and antimicrobial activity are reported.