181235-21-2Relevant academic research and scientific papers
Inhibitors of MMP-1: An examination of P1' C(α) gem-disubstitution in the succinamide hydroxamate series
Robinson, Ralph P.,Ragan, John A.,Cronin, Brian J.,Donahue, Kathleen M.,Lopresti-Morrow, Lori L.,Mitchell, Peter G.,Reeves, Lisa M.,Yocum, Sue A.
, p. 1719 - 1724 (2007/10/03)
The effect of P1' Cα gem-disubstitution in a series of succinamide hydroxamate inhibitors of MMP-1 has been investigated. While in all cases P1' gem-disubstitution led to loss of potency relative to the corresponding P1' isobutyl and phenyl compounds 1 and 3, respectively, the loss of activity was less pronounced in certain instances, e.g., the P1' gem-cyclohexyl analogue 12 (IC50 = 0.15 μM).
