18125-49-0 Usage
Uses
Antipyrine (A697500), a non-steroidal anti-inflammatory drug, is widely utilized as a probe for human oxidative drug metabolism. Antipyrine metabolites are formed by various hepatic cytochrome P450 enzymes. 3-Hydroxymethylantipyrine is a metabolite of Antipyrine.
Check Digit Verification of cas no
The CAS Registry Mumber 18125-49-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,2 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 18125-49:
(7*1)+(6*8)+(5*1)+(4*2)+(3*5)+(2*4)+(1*9)=100
100 % 10 = 0
So 18125-49-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O2/c1-12-10(8-14)7-11(15)13(12)9-5-3-2-4-6-9/h2-7,14H,8H2,1H3
18125-49-0Relevant articles and documents
An improved synthesis of 3-hydroxymethylantipyrine using antipyrine as starting material
Buijs,Van Meeteren-Walchli,Breimer,Van der Gen
, p. 419 - 421 (2007/10/02)
A partly new synthesis of 3-hydroxymethylantipyrine, an important metabolite of antipyrine in man and therefore frequently used as a reference substance, is described. The use of tri-n-butyltin hydride to reduce the vinyl bromide system in 3-hydroxymethyl