81122-69-2Relevant articles and documents
An improved synthesis of 3-hydroxymethylantipyrine using antipyrine as starting material
Buijs,Van Meeteren-Walchli,Breimer,Van der Gen
, p. 419 - 421 (2007/10/02)
A partly new synthesis of 3-hydroxymethylantipyrine, an important metabolite of antipyrine in man and therefore frequently used as a reference substance, is described. The use of tri-n-butyltin hydride to reduce the vinyl bromide system in 3-hydroxymethyl