181260-33-3

Upstream product

• 60-35-5 acetamide 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 

Downstream Products

• 125553-06-2 α-amino-(4'-fluorophenyl-)methanephosphonic acid 

Relevant academic research and scientific papers

Gold nanoparticles deposited on MnO2 nanorods modified graphene oxide composite: A potential ternary nanocatalyst for efficient synthesis of betti bases and bisamides

The decoration of novel nanostructures such as nano particle and nanorod on the surface of graphene oxide (GO) generate potential heterogeneous nanocatalyst. Highlighting this, in the present work, we have designed a ternary GO-MnO2-Au nanocomposite by decorating MnO2nanorods on the surface of graphene oxide via hydrothermal method, followed by deposition of Au nanoparticles on GO-MnO2 surface. The prepared nanocomposite was thoroughly characterised by different instrumental techniques such as X-Ray diffraction (XRD),Fourier transform infrared spectroscopy (FTIR),Raman spectroscopy, Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM), High resolution Transmission electron microscopy (HRTEM), X-Ray photo electron spectroscopy (XPS), N2 adsorption desorption Brunauer–Emmett–Teller (BET) isotherm and Inductively coupled plasma - optical emission spectrometry (ICP-OES). FESEM and TEM images demonstrated that the MnO2 forms rod like structure having diameter of 60–100 nm and are uniformly distributed over the GO surface. HRTEM image clearly signifies gold (Au) nanoparticles having diameter of 7 ± 1.9 nm homogeneously distributed throughout the GO-MnO2 surface. Elementary state of Au and tetravalent nature of Mn as well as reduction of functional group after the decoration was confirmed from XPS studies. The catalyst GO-MnO2-Au was found to be the superior catalyst for synthesis of biologically active molecules such as Betti bases and Bisamides. The high catalytic activity of the materials can be attributed to the small and homogeneous distribution of gold nanoparticles, high redox potential of rod shaped MnO2 and the synergistic effect between GO, MnO2 and Au. All the reaction conditions were optimised by varying catalyst dosage, effect of solvent and temperature. The GO-MnO2-Au was easily recycled with minimal leaching and the product yield was found to be 85–90% after 4th cycle demonstrating the stability and durability of our nanocomposite.

Choline peroxydisulfate oxidizing Bio-TSIL: Triple role player in the one-pot synthesis of Betti bases and gem-bisamides from aryl alcohols under solvent-free conditions

The one-pot, multicomponent solvent-free synthesis of Betti bases (amidoalkyl naphthols) and gem-bisamides directly from alcohol is proposed by an eco-friendly approach using a new environmentally benign, biodegradable, oxidizing, and task-specific ionic liquid (bio-TSIL), namely, choline peroxydisulfate monohydrate (ChPS) 1. Choline bisulphate (ChBS) 2 reduced species is then generated in situ from 1, which catalyses the formation of the desired products in a shorter reaction time with good to excellent yields. This bio-TSIL 1 plays a triple role as an oxidant, catalyst and solvent. It is easily recycled and can be reused five times.

Efficient synthesis of symmetrical bisamides from aldehydes and amides catalyzed by silica-bonded S-sulfonic acid nanoparticles

Silica-bonded S-sulfonic acid nanoparticles (SBSSANPs) were easily synthesized from silica nanoparticles and showed to be an efficient catalyst in the synthesis the symmetrical N,N′-alkylidene bisamides. Reaction of aldehydes and amides in the presence of the catalyst afforded the corresponding bisamides in good to excellent yields. The extensive range of substrates suggests general applicability of the method. Reusability of the catalyst, simple workup procedure, and short reaction times are other advantages of this protocol. Copyright

A mild, efficient, and environmentally friendly synthesis of N,N′-arylidene bisamides using B(HSO4)3 under solvent-free conditions

A green, efficient, and rapid procedure for the synthesis of N,N′-arylidene bisamide derivatives has been developed by one-pot condensation of aldehydes and amides in the presence of tris(hydrogensulfato) boron as a highly effective heterogeneous catalyst under solvent-free conditions at 100 C. Various aromatic aldehydes, acetamide or benzamide were used in the reaction, and in all cases the desired products were synthesised successfully. This method has the advantages of high yields, a clean reaction, an environmental friendly procedure, easy workup, simple methodology, and short reaction times.

Efficient synthesis of symmetrical N,N′-alkylidene bisamides catalysed by acetyl chloride

Symmetrical bisamides were synthesised from aldehydes and amides in the presence of distilled acetyl chloride. The reaction is rapid, clean and gives the products in excellent yields.

Silica-supported barium chloride (SiO2-BaCl2) - Efficient and heterogeneous catalyst for the environmentally friendly preparation of N, N ′-alkylidene bisamides under solvent-free conditions

A series of N,N′-alkylidene bisamides were prepared via a green and environmentally friendly synthetic protocol from the reaction of phenyl acetylene or hex-1-yne, aromatic aldehyde, and benzamide or acetamide. Silica-supported barium chloride (SiO2-BaCl2) catalyzes the process of the reaction. The prepared catalysts were characterized by X-ray diffraction, and the products were obtained with high conversions and yields.

One-pot preparation of N,N′-alkylidene bisamide derivatives catalyzed by silica supported magnesium chloride (SiO2-MgCl2)

A highly efficient and simple procedure for the preparation of N,N′-alkylidene bisamides via one-pot threecomponent condensation reaction of phenyl acetylene/1-Hexyne, aromatic aldehyde and benzamide/acetamide in the presence of catalytic amount of silica

Inhibitors of phenylalanine ammonialyase: 1-aminobenzylphosphonic acids substituted in the benzene ring

Dextrorotatory 1-amino-3′,4′-dichlorobenzylphosphonic acid was found to be a potent inhibitor of the plant enzyme phenylalanine ammonia-lyase both in vitro and in vivo from among the ring-substituted 1-aminobenzylphosphonic acids and other analogues of phenylglycine. A structure activity relationship analysis of the results obtained permits predictions on the geometry of the pocket of the enzyme and is a basis in the strategy of better inhibitor synthesis.

The preparation and characterization of some fluorinated α-aminoarylmethanephosphonic acids

α-Aminoarylmethanephosphonic acids have been prepared with a range of fluoro, fluoroalkyl, or fluoroalkoxy substituents in the benzene ring (4-F, 3-F, 2-F, 3,4-F2, F5, 4-CF3, 3-CF3, 4-CF3O, and 3-CF3O). These compounds have relatively low aqueous solubility and their NMR spectra (1H, 13C, 31P and 19F) were therefore recorded in D2O in the presence of an excess of alkali. Under these conditions, the ring substituents appear to have little effect on δp (15-18 ppm), or on the 1H and 13C parameters for the benzylic group (α-CH), which are mainly in the ranges observed for other types of α-aminoarylmethanephosphonic acids under alkaline conditions (δH 3.8-4.0 ppm, 2JPH 15.3-16.5 Hz; δC 57-58 ppm, 1JPC 128-132 Hz). For those examples with fluorine in the ortho position (i.e., the 2-fluoro and pentafluoro derivatives) a slightly higher field chemical shift was observed for the benzylic carbon atom (δC 50-51 ppm). In the fast-atom bombardment mass spectra, pseudo-molecular ions, MH+, and ions resulting from the elimination of phosphorous acid [MH - H3PO3]+, provide a further useful means of chararacterization for these compounds. Key words: Fluorinated aminoarylmethanephosphonic acids, dialkyl N-diphenylmethylaminoaryl-methanephosphonates, NMR spectroscopy, FAB mass spectrometry.