181270-85-9Relevant academic research and scientific papers
New 2-benzylsulfanyl-nicotinic acid based 1,3,4-oxadiazoles: Their synthesis and biological evaluation
Patel, Navin B.,Purohit, Amit C.,Rajani, Dhanji P.,Moo-Puc, Rosa,Rivera, Gildardo
, p. 677 - 687 (2013/05/09)
A novel series of 5-(2-benzylsulfanyl-pyridin-3-yl)-2-(substituted)- sulfanyl-1,3,4-oxadiazoles 6a-j were synthesized from key intermediate 5-(2-benzylsulfanyl-pyridin-3-yl)-3H-[1,3,4]oxadiazole-2-thione 5. Nucleophilic substitution reactions with differe
Synthesis, biological evaluation and molecular modeling studies of N-aryl-2-arylthioacetamides as non-nucleoside HIV-1 reverse transcriptase inhibitors
Xiaohe, Zhu,Yu, Qin,Hong, Yan,Xiuqing, Song,Rugang, Zhong
experimental part, p. 330 - 339 (2011/12/22)
A series of N-aryl-2-arylthioacetamide derivatives (2-4) designed as non-nucleoside reverse transcriptase inhibitors was synthesized and evaluated for their inhibitory activity against HIV-1 (IIIB) replication in MT-4 cell cultures. The compounds 2-4 were
Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives
Zhang, Shu Lan,Liu, Ya Jing,Zhao, Yan Fang,Guo, Qiu Ting,Gong, Ping
scheme or table, p. 1071 - 1074 (2011/10/05)
A series of 1,4-substituted phthalazine derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, HT-29 and MDA-MB-231 cell lines in vitro. Among them, compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC50 values from 1nmol/L to 0.92μmol/L. A preliminary SAR study of these derivatives was performed.
Synthesis and bioactivity of novel triazolo [1,5-a]pyrimidine derivatives[3]
Yang, Guangfu,Xu, Li,Lu, Aihong
, p. 491 - 496 (2007/10/03)
In an attempt to discover novel compounds with high herbicidal activity and low toxicity, a series of novel 1,2,4-triazolo[1,5-a]pyrimidine derivatives, α-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-thio)acetamides 3 and α-(5,7-dimethyl-1,2, 4-triazol
