181270-85-9

Basic information

• Product Name: acetamide, 2-chloro-N-(4,6-dimethoxy-2-pyrimidinyl)-
• Synonyms: 2-chloro-N-(4,6-dimethoxypyrimidin-2-yl)acetamide;acetamide, 2-chloro-N-(4,6-dimethoxy-2-pyrimidinyl)-
• CAS NO: 181270-85-9
• Molecular Formula: C8H10ClN3O3
• Molecular Weight: 231.6363
• Mol File: 181270-85-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: acetamide, 2-chloro-N-(4,6-dimethoxy-2-pyrimidinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: acetamide, 2-chloro-N-(4,6-dimethoxy-2-pyrimidinyl)-(181270-85-9)
• EPA Substance Registry System: acetamide, 2-chloro-N-(4,6-dimethoxy-2-pyrimidinyl)-(181270-85-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 181270-85-9(Hazardous Substances Data)

Upstream product

• 36315-01-2 4,6-dimethoxy-2-aminopyrimidine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1430236-00-2 C₂₂H₂₀N₆O₄S₂ 

Relevant articles and documents

New 2-benzylsulfanyl-nicotinic acid based 1,3,4-oxadiazoles: Their synthesis and biological evaluation

A novel series of 5-(2-benzylsulfanyl-pyridin-3-yl)-2-(substituted)- sulfanyl-1,3,4-oxadiazoles 6a-j were synthesized from key intermediate 5-(2-benzylsulfanyl-pyridin-3-yl)-3H-[1,3,4]oxadiazole-2-thione 5. Nucleophilic substitution reactions with differe

Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives

A series of 1,4-substituted phthalazine derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, HT-29 and MDA-MB-231 cell lines in vitro. Among them, compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC50 values from 1nmol/L to 0.92μmol/L. A preliminary SAR study of these derivatives was performed.