1813-69-0

Basic information

• Product Name: 2-(4-fluorophenyl)-2,3-dihydro-1H-perimidine
• Synonyms: 1H-Perimidine, 2-(4-fluorophenyl)-2,3-dihydro-; 2-(4-Fluorophenyl)-2,3-dihydro-1H-perimidine
• CAS NO: 1813-69-0
• Molecular Formula: C₁₇H₁₃FN₂
• Molecular Weight: 264.2969
• Mol File: 1813-69-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 493.3°C at 760 mmHg
• Flash Point: 252.1°C
• Density: 1.24g/cm³
• Vapor Pressure: 7.11E-10mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 2-(4-fluorophenyl)-2,3-dihydro-1H-perimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-2,3-dihydro-1H-perimidine(1813-69-0)
• EPA Substance Registry System: 2-(4-fluorophenyl)-2,3-dihydro-1H-perimidine(1813-69-0)

Safety Data

• Hazardous Substances Data: 1813-69-0(Hazardous Substances Data)

Usage

Heterocyclic compound

Contains a perimidine ring system and a fluorophenyl group

Pharmaceutical research and drug development

Used for its potential pharmacological properties

Anticonvulsant

Potential to prevent or reduce the severity of seizures

Antipsychotic

Potential to treat or alleviate symptoms of psychosis

Neurotransmitter receptor modulation

Ability to affect the activity of neurotransmitter receptors in the brain

Synthesis and characterization

Of interest to researchers in medicinal chemistry and drug discovery.

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 479-27-6 naphthalene-1,8-diamine 
• 459-57-4 4-fluorobenzaldehyde 

Relevant articles and documents

Phosphine-Free Well-Defined Mn(I) Complex-Catalyzed Synthesis of Amine, Imine, and 2,3-Dihydro-1 H-perimidine via Hydrogen Autotransfer or Acceptorless Dehydrogenative Coupling of Amine and Alcohol

The application of nontoxic, earth-abundant transition metals in place of costly noble metals is a paramount goal in catalysis and is especially interesting if the air- and moisture-stable ligand scaffold is used. Herein, we report the synthesis of amines/imines directly from alcohol and amines via hydrogen autotransfer or acceptorless dehydrogenation catalyzed by well-defined phosphine-free Mn complexes. Both imines and amines can be obtained from the same set of alcohols and amines using the same catalyst, only by tuning the reaction conditions. The amount and nature of the base are found to be a highly important aspect for the observed selectivity. Both the primary and secondary amines have been employed as substrates for the N-alkylation reaction. As a highlight, we showed the chemoselective synthesis of resveratrol derivatives. Furthermore, the Mn-catalyzed dehydrogenative synthesis of structurally important 2,3-dihydro-1H-perimidines has also been demonstrated. Density functional theory calculations were also carried out to model the reaction path and to calculate the reaction profile.

Decoration of β-CD-ZrO on Fe3O4 magnetic nanoparticles as a magnetically, recoverable and reusable catalyst for the synthesis of 2,3-dihydro-1H-perimidines

Abstract: This study focuses on covalent grafting of ZrO to β-CD to prepare an organic–inorganic hybrid material. The synthesised product was successfully linked on the surface of Fe3O4 magnetic nanoparticles and characterized by TGA

Fe3O4/SiO2/(CH2)3N+Me3Br3- core-shell nanoparticles: A novel catalyst for the solvent-free synthesis of five- and six-membered heterocycles

Functionalized magnetic core-shell nanoparticles [Fe3O4/SiO2/(CH2)3N+Me3Br3-] are prepared by co-precipitation method, characterized by transmission electron microscopy, FT-IR, X-ray diffraction, and vibrating sample magnetometer. The catalytic activity of these nanoparticles was tested in the syntheses of imidazole, benzothiazole, and perimidine derivatives, under solvent-free conditions. The catalyst was readily recycled by the use of an external magnetic field and could be reused five times without significant loss of activity or mass.